ArticleProceedings of the National Academy of Sciences of the United States of America2002
A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 113 citations in OpenAlex.
- Article
- Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential.F1000Research · 2018Article
- Review
- A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells.PLoS pathogens · 2015Article
- Protein as chemical cue: non-nutritional growth enhancement by exogenous protein in Pseudomonas putida KT2440.PloS one · 2014Article
- RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells.TheScientificWorldJournal · 2014Article
- Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity.Cell · 2013Article
- Structure and mechanism of rhomboid protease.The Journal of biological chemistry · 2013Review
- Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.Nature structural & molecular biology · 2012Article
- An Arabidopsis rhomboid protease has roles in the chloroplast and in flower development.Journal of experimental botany · 2012Article
- Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites.Biochemistry · 2012Article
- Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.PloS one · 2012Article
- The rhomboid protease family: a decade of progress on function and mechanism.Genome biology · 2011Review
- Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis.BMC microbiology · 2010Article
- The PARL family of mitochondrial rhomboid proteases.Seminars in cell & developmental biology · 2010Review
- Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis.The Biochemical journal · 2010Review
- Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.Nature reviews. Microbiology · 2009Review
- Inter-kingdom signaling: chemical language between bacteria and host.Current opinion in microbiology · 2009Review
- Structure and mechanism of intramembrane protease.Seminars in cell & developmental biology · 2009Review
- Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermal growth factor receptor (EGFr) is a key mediator of cell communication during animal development and homeostasis. In Drosophila, the signaling event is commonly regulated by the polytopic membrane protein Rhomboid (RHO), which mediates the proteolytic activation of EGFr ligands, allowing the secretion of the active signal. Until very recently, the biochemical function of RHO had remained elusive. It is now believed that Drosophila RHO is the founder member of a previously undescribed family of serine proteases, and that it could be directly responsible for the unusual, intramembranous cleavage of EGFr ligands. Here we show that the function of RHO is conserved in Gram-negative bacteria. AarA, a Providencia stuartii RHO-related protein, is active in Drosophila on the fly EGFr ligands. Vice versa, Drosophila RHO-1 can effectively rescue the bacterium's ability to produce or release the signal that activates density-dependent gene regulation (or quorum sensing). This study provides the first evidence that prokaryotic and eukaryotic RHOs could have a conserved role in cell communication and that their biochemical properties could be more similar than previously anticipated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.