ArticleThe Journal of nutrition2002
Energy restriction reduces fractional calcium absorption in mature obese and lean rats.
Article in The Journal of nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake.The American journal of clinical nutrition · 2007Trial
- Overweight postmenopausal women lose bone with moderate weight reduction and 1 g/day calcium intake.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005Trial
- Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women.The American journal of clinical nutrition · 2004Trial
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- The Influence of Different Degrees of Energy Restriction on Bone Parameters in Young Female Rats.Calcified tissue international · 2025Article
- Pathophysiological Aspects of Muscle Atrophy and Osteopenia Induced by Chronic Constriction Injury (CCI) of the Sciatic Nerve in Rats.International journal of molecular sciences · 2023Article
- Exercise training modifies the bone and endocrine response to graded reductions in energy availability in skeletally mature female rodents.Frontiers in endocrinology · 2023Article
- Fracture Risk in Vegetarians and Vegans: the Role of Diet and Metabolic Factors.Current osteoporosis reports · 2022Review
- Calcium status assessment at the population level: Candidate approaches and challenges.Annals of the New York Academy of Sciences · 2022Review
- Effects of Ovariectomy and Exercise Training on Mineral Status in a High-Fat Diet-Induced Obesity Rat Model.Biological trace element research · 2022Article
- Association of Vitamin D and Parathyroid Hormone Levels in Overweight and Obese Adolescents.Indian journal of clinical biochemistry : IJCB · 2020Article
- Article
- Exercise during energy restriction mitigates bone loss but not alterations in estrogen status or metabolic hormones.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice.Nutrition research (New York, N.Y.) · 2016Article
- Article
- Sex differences in adipose tissue: It is not only a question of quantity and distribution.Adipocyte · 2013Article
- Bone metabolism in obesity and weight loss.Annual review of nutrition · 2012Review
- Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats.Lipids in health and disease · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Weight loss is associated with bone loss and the risk may be greater in lean than heavier individuals, but the mechanisms involved remain unclear. We hypothesized that energy restriction (EnR) would decrease true fractional Ca absorption (TFCA) and be mediated by Ca-regulating hormones, but differently in obese and lean rats. Rats were fed a high fat (47% energy) or low fat (16% energy) diet for 4 mo. At 6 mo of age, the resulting lean [284 +/- 28g (mean +/- SD, n = 18)] and obese (319 +/- 34g, n = 20) groups (P < 0.005) were divided into controls (CTL, ad libitum) and energy-restricted (40% restriction) groups. At baseline, bone resorption (urinary crosslinks) was higher and bone formation (serum osteocalcin) was lower in obese than in lean rats, whereas Ca balance components and Ca-regulating hormones did not differ. EnR for 10 wk reduced body weight by 25 +/- 7% compared with a 6 +/- 6% gain in CTL rats (P < 0.001). For both lean and obese rats, TFCA (5-d measurement, (45)Ca radioisotope) decreased from 30 +/- 9% to 24 +/- 9% with EnR, compared with 25 +/- 10% to 29 +/- 11% in controls (P < 0.05). Weight loss was directly correlated with the decrease in TFCA (r = 0.34, P < 0.05). Uterine weights indicated a reduced estrogenic activity in energy-restricted rats (P < 0.0001). In lean, but not obese rats, serum estradiol (E(2)) correlated with weight loss (r = 0.52, P < 0.05), and tended to correlate with the decrease in TFCA (r = 0.48, P = 0.06). At the end of the study, serum 25-hydroxyvitamin-D was lower and urinary Ca was higher in lean than obese energy-restricted rats. Distinct endocrine profiles during weight loss in obese and lean rats suggest that the susceptibility of bone and Ca metabolism to EnR could differ depending on initial body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.