ArticleMolecular biology of the cell2002
A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion inGenetics · 2019Article
- Functional Dissection ofFrontiers in cellular neuroscience · 2019Article
- Importin α: functions as a nuclear transport factor and beyond.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.The Journal of cell biology · 2015Article
- Nuclear retention of importin α coordinates cell fate through changes in gene expression.The EMBO journal · 2012Article
- Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions.G3 (Bethesda, Md.) · 2012Article
- Karyopherins in nuclear transport of homeodomain proteins during development.Biochimica et biophysica acta · 2011Review
- Organization and regulation of nucleocytoplasmic transport.Molecular biology · 2010Review
- Evolution of the metazoan-specific importin alpha gene family.Journal of molecular evolution · 2009Article
- Nucleus-specific importin alpha proteins and nucleoporins regulate protein import and nuclear division in the binucleate Tetrahymena thermophila.Eukaryotic cell · 2008Article
- Regulation of nuclear lamin polymerization by importin alpha.The Journal of biological chemistry · 2008Article
- Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.Genetics · 2008Article
- Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates.The EMBO journal · 2005Article
- Article
- In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity.Molecular and cellular biology · 2004Article
- Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro.The EMBO journal · 2004Article
- Article
- Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The importin alpha family of nuclear-cytoplasmic transport factors mediates the nuclear localization of proteins containing classical nuclear localization signals. Metazoan animals express multiple importin alpha proteins, suggesting their possible roles in cell differentiation and development. Adult Caenorhabditis elegans hermaphrodites express three importin alpha proteins, IMA-1, IMA-2, and IMA-3, each with a distinct expression and localization pattern. IMA-2 was expressed exclusively in germ line cells from the early embryonic through adult stages. The protein has a dynamic pattern of localization dependent on the stage of the cell cycle. In interphase germ cells and embryonic cells, IMA-2 is cytoplasmic and nuclear envelope associated, whereas in developing oocytes, the protein is cytoplasmic and intranuclear. During mitosis in germ line cells and embryos, IMA-2 surrounded the condensed chromosomes but was not directly associated with the mitotic spindle. The timing of IMA-2 nuclear localization suggested that the protein surrounded the chromosomes after fenestration of the nuclear envelope in prometaphase. Depletion of IMA-2 by RNA-mediated gene interference (RNAi) resulted in embryonic lethality and a terminal aneuploid phenotype. ima-2(RNAi) embryos have severe defects in nuclear envelope formation, accumulating nucleoporins and lamin in the cytoplasm. We conclude that IMA-2 is required for proper chromosome dynamics in germ line and early embryonic mitosis and is involved in nuclear envelope assembly at the conclusion of mitosis.
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