ArticleMolecular biology of the cell2002
Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Functionality of Reactive Oxygen Species (ROS) in Plants: Toxicity and Control inPlants (Basel, Switzerland) · 2024Review
- Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.Nucleic acids research · 2021Article
- Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.Nucleic acids research · 2021Article
- Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect.Frontiers in microbiology · 2021Article
- Local potentiation of stress-responsive genes by upstream noncoding transcription.Nucleic acids research · 2016Article
- Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor.Molecular and cellular biology · 2015Article
- A stress-activated, p38 mitogen-activated protein kinase-ATF/CREB pathway regulates posttranscriptional, sequence-dependent decay of target RNAs.Molecular and cellular biology · 2013Article
- The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.Nucleic acids research · 2012Article
- A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.Cell cycle (Georgetown, Tex.) · 2011Article
- The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.The Journal of biological chemistry · 2010Article
- Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.Nucleic acids research · 2008Article
- Regulation of cell cycle and stress responses to hydrostatic pressure in fission yeast.Molecular biology of the cell · 2007Article
- Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.Molecular and cellular biology · 2007Article
- Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways.Molecular genetics and genomics : MGG · 2006Review
- Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling.Eukaryotic cell · 2006Article
- Stress-specific role of fission yeast Gcn5 histone acetyltransferase in programming a subset of stress response genes.Eukaryotic cell · 2006Article
- Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.Molecular and cellular biology · 2005Article
- Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast.Molecular and cellular biology · 2005Article
- The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe.Eukaryotic cell · 2004Article
- Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.Eukaryotic cell · 2004Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In Schizosaccharomyces pombe, the Sty1 mitogen-activated protein kinase and the Atf1 transcription factor control transcriptional induction in response to elevated salt concentrations. Herein, we demonstrate that two repressors, Tup11 and Tup12, and the Prr1 transcription factor also function in the response to salt shock. We find that deletion of both tup genes together results in hypersensitivity to elevated cation concentrations (K(+) and Ca(2+)) and we identify cta3(+), which encodes an intracellular cation transporter, as a novel stress gene whose expression is positively controlled by the Sty1 pathway and negatively regulated by Tup repressors. The expression of cta3(+) is maintained at low levels by the Tup repressors, and relief from repression requires the Sty1, Atf1, and Prr1. Prr1 is also required for KCl-mediated induction of several other Sty1-dependent genes such as gpx1(+) and ctt1(+). Surprisingly, the KCl-mediated induction of cta3(+) expression occurs independently of Sty1 in a tup11Delta tup12Delta mutant and so the Tup repressors link induction to the Sty1 pathway. We also report that in contrast to a number of other Sty1- and Atf1-dependent genes, the expression of cta3(+) is induced only by high salt concentrations. However, in the absence of the Tup repressors this specificity is lost and a range of stresses induces cta3(+) expression.
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