ArticleProceedings of the National Academy of Sciences of the United States of America2002
Molecular cloning and functional expression of the first insect FMRFamide receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 121 citations in OpenAlex.
- Flipped binding modes for the same agonist in closely related neuropeptide-gated ion channels.Biophysical journal · 2025Article
- FMRFamide-like peptides (FaLPs) - an overview of diverse physiological roles in insects and other arthropods.International journal of biological sciences · 2025Review
- Comparative analysis defines a broader FMRFamide-gated sodium channel family and determinants of neuropeptide sensitivity.The Journal of biological chemistry · 2022Article
- Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems.Molecular biology and evolution · 2021Article
- FMRFamide-Related Peptides Signaling Is Involved in the Regulation of Muscle Contractions in Two Tenebrionid Beetles.Frontiers in physiology · 2020Article
- Evolution of neuropeptide signalling systems.The Journal of experimental biology · 2018Review
- Neuropeptidergic integration of behavior inThe Journal of experimental biology · 2017Article
- The evolution of neuropeptide signalling: insights from echinoderms.Briefings in functional genomics · 2017Review
- An ancient FMRFamide-related peptide-receptor pair induces defence behaviour in a brachiopod larva.Open biology · 2017Article
- Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii.PloS one · 2017Article
- FMRFamide signaling promotes stress-induced sleep in Drosophila.Brain, behavior, and immunity · 2015Article
- Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci.Molecular brain · 2014Article
- Article
- Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.The EMBO journal · 2012Article
- More than two decades of research on insect neuropeptide GPCRs: an overview.Frontiers in endocrinology · 2012Article
- Reproduction-related sound production of grasshoppers regulated by internal state and actual sensory environment.Frontiers in neuroscience · 2012Article
- Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster.Frontiers in endocrinology · 2012Article
- Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A review of FMRFamide- and RFamide-like peptides in metazoa.Invertebrate neuroscience : IN · 2009Article
- Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms.Insect biochemistry and molecular biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
FMRFamide and FMRFamide-related neuropeptides are extremely widespread and abundant in invertebrates and have numerous important functions. Here, we have cloned a Drosophila orphan receptor, and stably expressed it in Chinese hamster ovary cells. Screening of a peptide library revealed that the receptor reacted with high affinity to FMRFamide (EC50, 6 x 10(-9) M). The intrinsic Drosophila FMRFamide peptides are known to be synthesized as a large preprohormone, containing at least 13 related FMRFamide peptides (8 distinct FMRFamides). Screening of these intrinsic Drosophila FMRFamides showed that the receptor had highest affinity to Drosophila FMRFamide-6 (PDNFMRFamide) (EC50, 9 x 10(-10) M), whereas it had a somewhat lower affinity to Drosophila FMRFamide-2 (DPKQDFMRFamide) (EC50, 3 x 10(-9) M) and considerably less affinity to the other Drosophila FMRFamide-related peptides. To our knowledge, this article is the first report on the molecular identification of an invertebrate FMRFamide receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.