ArticleProceedings of the National Academy of Sciences of the United States of America2002
Engineering growing tissues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 394 citations in OpenAlex.
- Assembly of complex cell microenvironments using geometrically docked hydrogel shapes.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- A Soft Microrobot for Single-Cell Transport, Spheroid Assembly, and Dual-Mode Drug Screening.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- 3D Printing of Chitosan Scaffolds and Films with Varying Roughness for Cultivation of Human Retinal Progenitor Cells.ACS omega · 2025Article
- Engineering Efferocytosis for Bone Regeneration.Macromolecular bioscience · 2025Review
- Challenges of engineering a functional growth plateFrontiers in bioengineering and biotechnology · 2025Review
- Peptide Hydrogels and Nanostructures Controlling Biological Machinery.Langmuir : the ACS journal of surfaces and colloids · 2023Review
- Research progress of functional motifs based on growth factors in cartilage tissue engineering: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Alginate microfibers as therapeutic delivery scaffolds and tissue mimics.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology.Advanced healthcare materials · 2022Review
- Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation.Journal of the mechanical behavior of biomedical materials · 2022Article
- Review
- Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage.Journal of biomechanics · 2021Article
- Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.Advanced drug delivery reviews · 2021Review
- Gelatin-Methacryloyl (GelMA) Formulated with Human Platelet Lysate Supports Mesenchymal Stem Cell Proliferation and Differentiation and Enhances the Hydrogel's Mechanical Properties.Bioengineering (Basel, Switzerland) · 2019Article
- Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair.Science advances · 2019Article
- Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration.Science translational medicine · 2019Article
- Biomaterial-based endochondral bone regeneration: a shift from traditional tissue engineering paradigms to developmentally inspired strategies.Materials today. Bio · 2019Review
- Three-dimensional alginate hydrogels for radiobiological and metabolic studies of cancer cells.Colloids and surfaces. B, Biointerfaces · 2018Article
- A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.Nature communications · 2018Article
- High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue.Nanotheranostics · 2018Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Regenerating or engineering new tissues and organs may one day allow routine replacement of lost or failing tissues and organs. However, these engineered tissues must not only grow to fill a defect and integrate with the host tissue, but often they must also grow in concert with the changing needs of the body over time. We hypothesized that tissues capable of growing with time could be engineered by supplying growth stimulus signals to cells from the biomaterial used for cell transplantation. In this study, chondrocytes and osteoblasts were cotransplanted on hydrogels modified with an RGD-containing peptide sequence to promote cell multiplication. New bone tissue was formed that grew in mass and cellularity by endochondral ossification in a manner similar to normal long-bone growth. Transplanted cells organized into structures that morphologically and functionally resembled growth plates. These engineered tissues could find utility in treating diseases and injuries of the growth plate, testing the effect of experimental drugs on growth-plate function and development, and investigating the biology of long-bone growth. Furthermore, this concept of promoting the growth of engineered tissues could find great utility in engineering numerous tissue types by way of the transplantation of a small number of precursor cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.