ArticleLipids2002
Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice.
Article in Lipids, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers.European journal of clinical nutrition · 2005Trial
- The Ethanol Extract ofMolecules (Basel, Switzerland) · 2019Article
- The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages.PloS one · 2015Article
- Effect of CLA isomers and their mixture on aging C57Bl/6J mice.European journal of nutrition · 2009Article
- Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA.Nutrition research and practice · 2008Article
- Article
- Effects of cis-9,trans-11 CLA in rats at intake levels reported for breast-fed infants.Lipids · 2006Article
- Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice.Lipids · 2006Article
- Increased immune response in mice consuming rice bran oil.European journal of nutrition · 2005Article
- Article
- Article
- Review
- Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium.Journal of mammary gland biology and neoplasia · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Published results regarding the effects of CLA on immune cell functions have ranged from stimulation to inhibition. In those studies, a mixture of CLA isomers were used, and food intake was not controlled. We have examined whether the discrepancies in the results of earlier studies may be due to the lack of controlled feeding and whether the two isomers of CLA may differ in their effects on immune cell functions. Three groups of C57BL/6 female mice were fed either a control, c9,t11-CLA-, or t10,c12-CLA (0.5 wt%)-supplemented diet, 5 g/d, for 56 d. At the end of the study, the number of immune cells in spleens, bone marrows, or in circulation; proliferation of splenocytes in response to T and B cell mitogens; and prostaglandin secretion in vitro did not differ among the three groups. Both CLA isomers significantly increased in vitro tumor necrosis factor alpha and interleukin (IL)-6 secretion and decreased IL-4 secretion by splenocytes compared to those in the control group. Thus, the two CLA isomers had similar effects on all response variables tested. The discrepancies among the results from previous studies did not seem to be caused by the differences in the isomer composition of CLA used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.