ArticleGenes and immunity2002
The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3).
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- CTLA-4 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis.Genetic testing and molecular biomarkers · 2013Pooled it
- CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.Human genetics · 2005Pooled it
- A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients.JCI insight · 2020Article
- Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.Journal of the American Society of Nephrology : JASN · 2014Article
- End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Hominoid fission of chromosome 14/15 and the role of segmental duplications.Genome research · 2013Article
- Prevalence of genetic renal disease in children.Pediatric nephrology (Berlin, Germany) · 2013Article
- A novel pathogenetic concept-antiviral immunity in lupus nephritis.Nature reviews. Nephrology · 2012Review
- Glomerular diseases: genetic causes and future therapeutics.Nature reviews. Nephrology · 2010Review
- Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.Seminars in nephrology · 2010Article
- Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation.Genes and immunity · 2009Review
- Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.The Journal of experimental medicine · 2008Article
- Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus.The Journal of rheumatology · 2007Article
- An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP).Human genetics · 2007Article
- Current status of lupus genetics.Arthritis research & therapy · 2007Review
- Unraveling the genetics of systemic lupus erythematosus.Springer seminars in immunopathology · 2006Review
- Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus.Genes and immunity · 2006Article
- Current advances in the human lupus genetics.Current rheumatology reports · 2004Review
- SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis.American journal of human genetics · 2004Article
- T-helper cell tolerance to ubiquitous nuclear antigens.Scandinavian journal of immunology · 2003Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Renal disease occurs in 40-75% of systemic lupus erythematosus (SLE) patients and significantly contributes to morbidity and mortality. We used two pedigree stratification strategies to explore the impact of the ACR renal criterion for SLE classification upon genetic linkage with SLE. In both we used SLE as the phenotype. First, we evaluated genome scan data from >300 microsatellite markers in the 75 pedigrees that had at least one SLE affected with the SLE renal criterion. A maximum-likelihood parametric model approach produced a maximum screening LOD score of 3.16 at 10q22.3 in the European-American (EA) pedigrees. The African-American (AA) pedigrees obtained a maximum screening LOD score of 2.58 at 11p15.6. A multipoint sib-pair regression analysis produced P = 0.0000008 in EA at 10q22.3 (SLEN1) and P = 0.000001 in AA at 2q34-35 (SLEN2). A second stratification strategy explored the renal criterion in 35 pedigrees with two or more SLE patients with renal disease and produced a LOD score of 3.34 at 11p15.6 in AA (SLEN3). Sib-pair analysis in these 35 pedigrees revealed P = 0.00003 at 4q13.1 in EA, P = 0.00003 at 11p13 and 0.00007 at 3q23 in AA. Thus, multiple genetic linkages are related to the renal criterion in SLE. Of the significant genetic linkages with SLE described herein, those at 10q22.3 in the EA pedigrees (SLEN1) and at 2q34-35 in the AA pedigrees (SLEN2) have not been previously described.
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