ArticleGenes and immunity2002
A genome screen of systemic lupus erythematosus using affected-relative-pair linkage analysis with covariates demonstrates genetic heterogeneity.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.Genes and immunity · 2006Pooled it
- Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause.Immunology · 2026Article
- Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.Arthritis research & therapy · 2017Article
- Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus.G3 (Bethesda, Md.) · 2016Article
- One novel susceptibility locus associate with systemic lupus erythematosus in Chinese Han population.Rheumatology international · 2013Article
- Fcgamma receptors: structure, function and role as genetic risk factors in SLE.Genes and immunity · 2009Review
- Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.European journal of human genetics : EJHG · 2009Article
- Interferon-inducible Ifi200-family genes in systemic lupus erythematosus.Immunology letters · 2008Review
- Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans.Human genetics · 2007Article
- Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.Genes and immunity · 2005Article
- Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members.Human genetics · 2005Article
- Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3.American journal of human genetics · 2004Article
- Looking back and looking forward.Genes and immunity · 2003Article
- The genetic etiology of systemic lupus erythematosus: a short dispatch from the combat zone.Genes and immunity · 2002Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Systemic lupus erythematosus (SLE) appears to be the consequence of complex genetics and of only partly understood environmental contributions. Previous work by ourselves and by others has established genetic effects on 1q, 2q, 4p, 6p, and 16p using SLE as the phenotype. However, individual SLE affecteds are extraordinarily different from one another by clinical and laboratory measures. This variation may have a genetic basis; if so, it is advantageous to incorporate measures of between-family clinical variability as covariates in a genetic linkage analysis of affected relative pairs (ARPs) to allow for locus heterogeneity. This approach was applied to genome scan marker data from 160 pedigrees multiplex for SLE and containing 202 ARPs. Because the number of potential covariates was large, we used both ad hoc methods and formal principal components analysis to construct four composite covariates using the SLE classification criteria plus age of onset, ethnicity, and sex. Linkage analysis without covariates has detected evidence for linkage at 1q22-24, 2q37, 4p16, 12p12-11, and 17p13. Linkage analysis with these covariates uncovered linkage at 13p11, 17q11-25, and 20q12 and greatly improved evidence for linkage at 1q22-24, 2q37, 12p12-11, and 17p13. Follow-up analysis identified the original variables contributing to locus heterogeneity in each of these locations. In conclusion, allowing for locus heterogeneity through the incorporation of covariates in linkage analysis is a useful way to dissect the genetic contributions to SLE and uncover new genetic effects.
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