ArticleMolecular and cellular biology2002
Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- The general transcription factors (GTFs) of RNA polymerase II and their roles in plant development and stress responses.Critical reviews in biochemistry and molecular biology · 2024Review
- Article
- Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies.Viruses · 2019Review
- Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium.Genome research · 2012Article
- Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.The Journal of biological chemistry · 2009Article
- TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation.Molecular and cellular biology · 2009Article
- Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II.Nucleic acids research · 2008Article
- TFIIB and the regulation of transcription by RNA polymerase II.Chromosoma · 2007Review
- Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid deprivation of HepG2 cells.The Journal of nutrition · 2006Article
- Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.EMBO reports · 2006Article
- A core promoter element downstream of the TATA box that is recognized by TFIIB.Genes & development · 2005Article
- Evidence that the Tfg1/Tfg2 dimer interface of TFIIF lies near the active center of the RNA polymerase II initiation complex.Nucleic acids research · 2005Article
- Nutritional control of gene expression: how mammalian cells respond to amino acid limitation.Annual review of nutrition · 2005Review
- Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation.Molecular and cellular biology · 2004Article
- A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment.Molecular and cellular biology · 2004Article
- Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB.The Biochemical journal · 2004Article
- A conformational change in TFIIB is required for activator-mediated assembly of the preinitiation complex.Nucleic acids research · 2004Article
- Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The general transcription factor TFIIB plays a central role in the selection of the transcription initiation site. The mechanisms involved are not clear, however. In this study, we analyze core promoter features that are responsible for the susceptibility to mutations in TFIIB and cause a shift in the transcription start site. We show that TFIIB can modulate both the 5' and 3' parameters of transcription start site selection in a manner dependent upon the sequence of the initiator. Mutations in TFIIB that cause aberrant transcription start site selection concentrate in a region that plays a pivotal role in modulating TFIIB conformation. Using epitope-specific antibody probes, we show that a TFIIB mutant that causes aberrant transcription start site selection assembles at the promoter in a conformation different from that for wild-type TFIIB. In addition, we uncover a core promoter-dependent effect on TFIIB conformation and provide evidence for novel sequence-specific TFIIB promoter contacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.