ArticleThe Plant cell2002
Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- TOP1α-mediated stabilization of CYP82C4 G-quadruplex DNA represses lateral root primordium initiation in Arabidopsis.Nature plants · 2026Article
- Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants.Journal of advanced research · 2025Review
- DNA TOP1α coordinates anther morphogenesis and fertility through gene regulatory networks in arabidopsis.Scientific reports · 2025Article
- Article
- TOP1α fine-tunes TOR-PLT2 to maintain root tip homeostasis in response to sugars.Nature plants · 2022Article
- A plant-specific module for homologous recombination repair.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phyllotaxis: from classical knowledge to molecular genetics.Journal of plant research · 2021Review
- Chromatin-based mechanisms to coordinate convergent overlapping transcription.Nature plants · 2021Article
- Exploring microRNA Signatures of DNA Damage Response Using an Innovative System of Genotoxic Stress inFrontiers in plant science · 2021Article
- SIMON: Simple methods for analyzing DNA methylation by targeted bisulfite next-generation sequencing.Plant biotechnology (Tokyo, Japan) · 2019Article
- Article
- DNA Topoisomerase Iα Affects the Floral Transition.Plant physiology · 2017Article
- Endocidal Regulation of Secondary Metabolites in the Producing Organisms.Scientific reports · 2016Article
- A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.Plant physiology · 2016Article
- TOPOISOMERASE1α Acts through Two Distinct Mechanisms to Regulate Stele and Columella Stem Cell Maintenance.Plant physiology · 2016Article
- Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco.Frontiers in plant science · 2016Article
- Genomic Signature of Selective Sweeps Illuminates Adaptation of Medicago truncatula to Root-Associated Microorganisms.Molecular biology and evolution · 2015Article
- Epigenetic Mechanisms Are Critical for the Regulation of WUSCHEL Expression in Floral Meristems.Plant physiology · 2015Review
- The never-ending story: from pluripotency to plant developmental plasticity.Development (Cambridge, England) · 2015Review
- A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis.The Plant cell · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genesis of phyllotaxis, which often is associated with the Fibonacci series of numbers, is an old unsolved puzzle in plant morphogenesis. Here, we show that disruption of an Arabidopsis topoisomerase (topo) I gene named TOP1alpha affects phyllotaxis and plant architecture. The divergence angles and internode lengths between two successive flowers were more random in the top1alpha mutant than in the wild type. The top1alpha plants sporadically produced multiple flowers from one node, and the number of floral organ primordia often was different. The mutation also caused the twisting of inflorescences and individual flowers and the serration of leaf margins. These morphological abnormalities indicate that TOP1alpha may play a critical role in the maintenance of a regular pattern of organ initiation. The top1alpha mutant transformed with the RNA interference construct for TOP1beta, another topo I gene arrayed tandemly with TOP1alpha, was found to be lethal at young seedling stages, suggesting that topo I activity is essential in plants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.