Evidence map›Paper›PMID 12214269›Full record

ArticleOncogene2002

Gene expression in epithelial ovarian carcinoma.

Daniela Matei, Thomas G Graeber, Rae Lynn Baldwin, Beth Y Karlan, Jianyu Rao, David D Chang

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Formation of the Bovine Ovarian Surface Epithelium during Fetal Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Tissue transglutaminase regulates β-catenin signaling through a c-Src-dependent mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013
    Article
  14. Angiogenesis-related pathways in the pathogenesis of ovarian cancer.International journal of molecular sciences · 2013
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniela MateiDepartment of Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California, CA 90095, USA.
Thomas G Graeber
Rae Lynn Baldwin
Beth Y Karlan
Jianyu Rao
David D Chang
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

ACADEMIC TRAINING IN MEDICAL ONCOLOGYT32CA009297 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RIBAS, ANTONI · 1985 to 2013
$3.3M
NCI NIH HHS T32CA09297
6 · The paper itself

Abstract

We analysed the mRNA levels corresponding to 12,600 transcripts in primary cultures of ovarian epithelial cells derived from nine normal ovaries and 21 epithelial ovarian carcinoma. The class distinction and hierarchical clustering of expression data revealed a clear distinction in gene expression between normal and carcinoma-derived ovarian epithelial cells. Comparison of expression levels revealed 111 genes with mean expression values of >2.5-fold higher in carcinoma cells. Similarly, 62 genes were expressed at >2.5-fold higher levels in normal ovarian epithelial cells. For a few selected genes, we demonstrate that the pattern of differential expression observed in cultured epithelial cells is present in the normal ovaries and epithelial ovarian carcinoma. Use of cultured epithelial cells represents a novel strategy to study gene expression in a cell-type specific manner.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticFemaleHumansMolecular Sequence DataOligonucleotide Array Sequence AnalysisOvarian NeoplasmsReverse Transcriptase Polymerase Chain Reaction

Identifiers

PMID12214269
OpenAlexW2330457397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.