ArticleThe Journal of cell biology2002
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 82 citations in OpenAlex.
- The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control.International journal of molecular sciences · 2020Review
- Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction.Nature communications · 2018Article
- CDC14A phosphatase is essential for hearing and male fertility in mouse and human.Human molecular genetics · 2018Article
- Identification of Cdk targets that control cytokinesis.The EMBO journal · 2015Article
- The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.Molecular cell · 2013Article
- Cytokinesis-required Cdc14 is a signaling hub of asexual development and multi-stress tolerance in Beauveria bassiana.Scientific reports · 2013Article
- Phosphatases: providing safe passage through mitotic exit.Nature reviews. Molecular cell biology · 2011Review
- The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.Cell cycle (Georgetown, Tex.) · 2011Article
- Article
- Calcineurin activity is required for the completion of cytokinesis.Cellular and molecular life sciences : CMLS · 2010Article
- Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.Nature cell biology · 2010Article
- Understanding cytokinesis failure.Advances in experimental medicine and biology · 2010Review
- INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.The Journal of cell biology · 2009Article
- The CDC14A phosphatase regulates oocyte maturation in mouse.Cell cycle (Georgetown, Tex.) · 2009Article
- Cdk-counteracting phosphatases unlock mitotic exit.Current opinion in cell biology · 2008Review
- Architecture of the sporulation-specific Cdc14 promoter from the oomycete Phytophthora infestans.Eukaryotic cell · 2007Article
- Cdc14-regulated midzone assembly controls anaphase B.The Journal of cell biology · 2007Article
- The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers.Molecular cancer · 2006Article
- The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules.Molecular and cellular biology · 2005Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In all eukaryotic organisms, the physical separation of two nascent cells must be coordinated with chromosome segregation and mitotic exit. In Saccharomyces cerevisiae and Schizosaccharomyces pombe this coordination depends on a number of genes that cooperate in intricate regulatory pathways termed mitotic exit network and septum initiation network, respectively. Here we have explored the function of potentially homologous genes in a metazoan organism, Caenorhabditis elegans, using RNA-mediated interference. Of all the genes tested, only depletion of CeCDC-14, the C. elegans homologue of the budding yeast dual-specificity phosphatase Cdc14p (Clp1/Flp1p in fission yeast), caused embryonic lethality. We show that CeCDC-14 is required for cytokinesis but may be dispensable for progression of the early embryonic cell cycles. In response to depletion of CeCDC-14, embryos fail to establish a central spindle, and several proteins normally found at this structure are mislocalized. CeCDC-14 itself localizes to the central spindle in anaphase and to the midbody in telophase. It colocalizes with the mitotic kinesin ZEN-4, and the two proteins depend on each other for correct localization. These findings identify the CDC14 phosphatase as an important regulator of central spindle formation and cytokinesis in a metazoan organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.