ReviewThe Journal of cell biology2002
Integrin activation takes shape.
Review in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed.
- Allosteric Disulfide Bridges in Integrins: The Molecular Switches of Redox Regulation of Integrin-Mediated Cell Functions.Antioxidants (Basel, Switzerland) · 2025Review
- Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation.APL bioengineering · 2025Review
- Integrins and their potential roles in mammalian pregnancy.Journal of animal science and biotechnology · 2023Review
- Integrin Regulators in Neutrophils.Cells · 2022Review
- Mechanical regulation of bone remodeling.Bone research · 2022Review
- Avian Eggshell Membrane as a Novel Biomaterial: A Review.Foods (Basel, Switzerland) · 2021Review
- Challenges and strategies forBioactive materials · 2021Review
- Borax-loaded injectable alginate hydrogels promote muscle regeneration in vivo after an injury.Materials science & engineering. C, Materials for biological applications · 2021Article
- Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway.Communications biology · 2020Article
- Article
- pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.Cancers · 2020Review
- Phthiocerol Dimycocerosates FromFrontiers in cellular and infection microbiology · 2020Article
- Coarse-Grained Simulation of Full-Length Integrin Activation.Biophysical journal · 2019Article
- HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target β-catenin.Molecular and cellular biochemistry · 2019Article
- Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at theeLife · 2018Article
- RGD-presenting peptides in amphiphilic and anionic β-sheet hydrogels for improved interactions with cells.RSC advances · 2018Article
- Anti-fibronectin aptamers improve the colonization of chitosan films modified with D-(+) Raffinose by murine osteoblastic cells.Journal of materials science. Materials in medicine · 2017Article
- Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration.Frontiers in immunology · 2017Article
- Atomic-level description of protein-lipid interactions using an accelerated membrane model.Biochimica et biophysica acta · 2016Review
- Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist.Nature communications · 2016Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand-binding domain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.