ArticleTransgenic research2002
Targeted expression of human serum albumin to potato tubers.
Article in Transgenic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
- Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming.Plant biotechnology journal · 2026Review
- Review
- Identification of essential element determining fruit-specific transcriptional activity in the tomato HISTIDINE DECARBOXYLASE A gene promoter.Plant cell reports · 2022Article
- Purslane (Portulaca oleracea L.) as a novel green-bioreactor for expression of human serum albumin (HSA) gene.Transgenic research · 2022Article
- Transient expression of human serum albumin (HSA) in tobacco leaves.Molecular biology reports · 2020Article
- Potential of plants to produce recombinant protein products.Journal of plant biology = Singmul Hakhoe chi · 2016Review
- Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells.PloS one · 2014Article
- Temporal and spatial control of gene expression in horticultural crops.Horticulture research · 2014Review
- Expression and purification of recombinant human serum albumin from selectively terminable transgenic rice.Journal of Zhejiang University. Science. B · 2013Article
- Improving pharmaceutical protein production in Oryza sativa.International journal of molecular sciences · 2013Review
- Stable plastid transformation for high-level recombinant protein expression: promises and challenges.Journal of biomedicine & biotechnology · 2012Article
- Large-scale production of functional human serum albumin from transgenic rice seeds.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Evolution of plant-made pharmaceuticals.International journal of molecular sciences · 2011Review
- Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.).Protein expression and purification · 2010Article
- Enhancement of tolerance to soft rot disease in the transgenic Chinese cabbage (Brassica rapa L. ssp. pekinensis) inbred line, Kenshin.Plant cell reports · 2009Article
- Production of recombinant albumin by a herd of cloned transgenic cattle.Transgenic research · 2009Article
- A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65).BMC biotechnology · 2008Article
- The potato-specific apyrase is apoplastically localized and has influence on gene expression, growth, and development.Plant physiology · 2008Article
- The sweet potato sporamin promoter confers high-level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato.Plant molecular biology · 2008Article
- Cell engineering and molecular pharming for biopharmaceuticals.The open medicinal chemistry journal · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complementary DNA expression of mature human serum albumin was engineered into potato plants under the transcriptional control of patatin B33 promoter and potato proteinase inhibitor II terminator. Protein secretion was achieved by using the signal sequence from potato proteinase inhibitor II. Recombinant albumin accumulated up to 0.2% of total soluble tuber protein in single transformant lines, regardless of the potato cultivar used. Electrophoretic mobility and N-terminal amino acid sequence analysis of partially purified recombinant albumin confirmed proper processing of an immune responsive recombinant albumin, and revealed that the proteinase inhibitor II signal sequence was correctly removed. No further optimisation of these yields was obtained by HSA expression in patatin antisense plants (line Pas58). Subcellular localisation showed that recombinant protein was successfully targeted to the apoplast. Potato tubers may be used, by applying this technology, to produce other heterologous proteins of interest in the biopharmaceutical industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.