ArticleJournal of molecular neuroscience : MN
The genetics of exceptional human longevity.
Article in Journal of molecular neuroscience : MN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Article
- Understanding the coupled relationship between regional longevity and physical geographical environment in Hechi, Guangxi, China.Scientific reports · 2024Article
- Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study.BMC geriatrics · 2022Article
- Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).Medicina (Kaunas, Lithuania) · 2020Article
- Inflammaging in Endemic Areas for Infectious Diseases.Frontiers in immunology · 2020Review
- Artificial Intelligence Based Approaches to Identify Molecular Determinants of Exceptional Health and Life Span-An Interdisciplinary Workshop at the National Institute on Aging.Frontiers in artificial intelligence · 2019Review
- Age-Related Biomarkers in LLFS Families With Exceptional Cognitive Abilities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Article
- Identification of genes promoting skin youthfulness by genome-wide association study.The Journal of investigative dermatology · 2014Article
- Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.PloS one · 2014Article
- Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.Age (Dordrecht, Netherlands) · 2013Article
- A common copy number variation (CNV) polymorphism in the CNTNAP4 gene: association with aging in females.PloS one · 2013Article
- Health among Swedish employees and financial situation, education, and managerial responsibility: a longitudinal study.Upsala journal of medical sciences · 2012Article
- How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging.Age (Dordrecht, Netherlands) · 2011Review
- Article
- Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin.Acta biomaterialia · 2009Article
- Adiponectin levels and genotype: a potential regulator of life span in humans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Article
- The most pressing problem of our age.BMJ (Clinical research ed.) · 2003Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How we age as individuals is no doubt a complex interaction of genetic and environmental factors. Studies of certain populations with optimal environments and health-related behaviors, as well as twin studies, suggest that the average set of genetic variations should facilitate the average person's ability to live to around age 85. Average life expectancies are lower than this because we generally fight survival advantage with bad health habits that can lead to premature aging, chronic illness, and death at a significantly younger age. Centenarians on the other hand live 15-25 years beyond what the average collection of us are able to achieve. Many of them have a history of aging relatively slowly, and either markedly delaying or even escaping lethal diseases associated with aging (Alzheimer's disease, stroke, cancer, cardiovascular disease, and diabetes). In order to live to such old age, centenarians are less likely to have genetic and environmental exposures that would cause at least lethal diseases at younger ages. Demographic selection is the drop out within a cohort, of genotypes linked to age-related lethal diseases and premature mortality as the cohort achieves older and older age. The result is a very old cohort that lacks these genotypes relative to younger age groups. Recent pedigree and molecular genetic studies indicate that scientists can use this selection to their advantage in discerning genotypes that play important roles in delaying or escaping diseases such as Alzheimer's disease, and in slowing the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.