Trial reportEuropean journal of clinical nutrition2002
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.
Trial report in European journal of clinical nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 151 citations in OpenAlex.
- Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.International journal of medical sciences · 2011Trial
- Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.European journal of clinical nutrition · 2003Trial
- A Minor Groove Binder with Significant Cytotoxicity on Human Lung Cancer Cells: The Potential of Hesperetin Functionalised Silver Nanoparticles.Journal of fluorescence · 2024Article
- Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E.Virology · 2022Article
- Are Antiviral Flavonoids Part of the Solution to the COVID-19 Pandemic?Integrative medicine (Encinitas, Calif.) · 2021Article
- Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells.Archives of toxicology · 2021Article
- Dietary flavonoids and flavonoid-rich foods: validity and reproducibility of FFQ-derived intake estimates.Public health nutrition · 2020Article
- Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation.Pharmaceutics · 2020Article
- Curcumin and hesperetin attenuate D-galactose-induced brain senescenceNutrition research and practice · 2020Article
- Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?International journal of molecular sciences · 2020Review
- Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation.Pharmaceutics · 2019Article
- Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries.Nutrients · 2017Article
- The Role of Natural Polyphenols in the Prevention and Treatment of Cervical Cancer-An Overview.Molecules (Basel, Switzerland) · 2016Review
- Efficacy of naringenin against permethrin-induced testicular toxicity in rats.International journal of experimental pathology · 2016Article
- Comparative inhibitory potential of selected dietary bioactive polyphenols, phytosterols on CYP3A4 and CYP2D6 with fluorometric high-throughput screening.Journal of food science and technology · 2015Article
- Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women.The Journal of nutrition · 2015Article
- Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors.Current atherosclerosis reports · 2013Review
- Bioavailability of bioactive food compounds: a challenging journey to bioefficacy.British journal of clinical pharmacology · 2013Review
- Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.Interdisciplinary toxicology · 2011Article
- Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet-cancer relationship in humans.European journal of nutrition · 2008Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the fasting plasma concentrations of quercetin, hesperetin and naringenin in human subjects consuming their habitual diets, and diets either high or low in fruit and vegetables. To investigate whether plasma concentrations of flavanones can serve as biomarkers of their intake.
designThis was a cross-over, strictly controlled dietary intervention consisting of a 2 week baseline period, and two 5 week dietary periods with a 3 week wash-out period in between. The low-vegetable diet contained few fruit and vegetables and no citrus fruit. The high-vegetable diet provided various fruits and vegetables daily including on average one glass of orange juice, one-half orange and one-half mandarin. SUBJECTS: Thirty-seven healthy females.
resultsThe high-vegetable diet provided 132 mg of hesperetin and 29 mg of naringenin. The low-vegetable diet contained no flavanones. The mean plasma hesperetin concentration increased from 12.2 nmol/l after the low-vegetable diet to 325 nmol/l after the high-vegetable diet. The respective increase for naringenin was from <73.5 nmol/l for all subjects to a mean value of 112.9 nmol/l. The mean plasma quercetin concentration was 52 nmol/l after the baseline period, during which habitual diets were consumed, and it did not change significantly during the intervention. Interindividual variation in the plasma levels of hesperetin and naringenin was marked and, after the baseline and wash-out periods, and the low-vegetable diet, a majority of the samples had plasma flavanone levels below the limit of detection. After the high-vegetable diet, hesperetin and naringenin were detectable in 54 and 22% of all samples. Quercetin was detectable in nearly all samples after all study periods.
conclusionHesperetin, naringenin and quercetin are bioavailable from the diet, but the plasma concentrations of hesperetin and naringenin are poor biomarkers of intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.