ArticleGenes and immunity2002
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese.Scientific reports · 2017Trial
- Scavenger receptor class B type I genetic variants associated with disease severity in chronic hepatitis C virus infection.Journal of medical virology · 2023Article
- Familial hypercholesterolemia and COVID-19: A menacing but treatable vasculopathic condition.Atherosclerosis plus · 2021Article
- Coronavirus and Cardiometabolic Syndrome: JACC Focus Seminar.Journal of the American College of Cardiology · 2020Review
- APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism.BMC gastroenterology · 2018Article
- Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response.World journal of gastroenterology · 2015Article
- PharmGKB summary: peginterferon-α pathway.Pharmacogenetics and genomics · 2015Article
- Association of apolipoprotein E with the progression of hepatitis B virus-related liver disease.International journal of clinical and experimental pathology · 2015Article
- Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.World journal of gastroenterology · 2014Review
- Association of low-density lipoprotein receptor genotypes with hepatitis C viral load.Genes and immunity · 2014Article
- Clinical utility of pharmacogenomics in the management of hepatitis C.Pharmacogenomics and personalized medicine · 2014Review
- Effects of the genetic pattern defined by low-density lipoprotein receptor and IL28B genotypes on the outcome of hepatitis C virus infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Review
- Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index.The Journal of infectious diseases · 2010Article
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.The Journal of infectious diseases · 2010Article
- Role of host genetics in fibrosis.Fibrogenesis & tissue repair · 2009Article
- 3' end mRNA processing: molecular mechanisms and implications for health and disease.The EMBO journal · 2008Review
- Factors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis.Journal of clinical microbiology · 2007Article
- Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.Journal of medical genetics · 2006Article
- Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The low-density lipoprotein receptor (LDLR) has been proposed to promote hepatitis C virus endocytosis and the cell membrane protein CD81 may also promote HCV host cell entry. The CD81 gene was sequenced to screen for novel polymorphisms, but no SNPs were identified. Polymorphisms within the LDLR gene are associated with the pathogenesis of familial hypercholesterolemia, atherosclerosis and obesity. We therefore studied genetic variation within the LDLR gene and clinical features of hepatitis C infection. An amino acid change in exon 8 was associated with severity of fibrosis; a SNP in exon 10 correlated with viral clearance and overall inflammation, and a SNP in the 3'UTR appeared to influence treatment response. There were no other significant associations between any of the SNPs studied and the clinical measures of hepatitis C infection. We furthermore report on linkage disequilibrium within the gene and haplotype frequencies in our population. Our findings support a possible role for the LDLR in the modulation of disease progression by affecting immune responses, rather than functioning as receptor for HCV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.