Evidence map›Paper›PMID 12209355›Full record

ArticleBone marrow transplantation2002

Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients.

D Jenkins, L DiFrancesco, A Chaudhry, D Morris, S Glück, A Jones, R Woodman, C B Brown, J Russell, D A Stewart

Registry-linked trialAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00619671 (Phase 1-2 Pilot Study of Rituximab), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00619671 phase1 / phase2completednot on this mapstarted 2004, after this paper: background citation

Phase 1-2 Pilot Study of Rituximab (Rituxan) in Refractory Myasthenia Gravis.

TypeinterventionalSponsorUniversity of VermontRan2004 to 2009Enrolled10ConditionsRefractory Myasthenia GravisArmsRituximab (Rituxan)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

D JenkinsDepartment of Medicine, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada.
L DiFrancesco
A Chaudhry
D Morris
S Glück
A Jones
R Woodman
C B Brown
J Russell
D A Stewart
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma. The first two cases received ASCT for MM, one with a CD34-selected autograft and the other with an unmanipulated autograft. Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN). The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma. He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN. None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years. These cases highlight the importance of considering PTLD in the differential diagnosis of lymphadenopathy and fever post ASCT. They also demonstrate the possibility of durable complete remission of post-ASCT PTLD following antiviral and immune modulating therapy.

Indexed as

AdultAntineoplastic AgentsAntiviral AgentsDiagnosis, DifferentialHumansImmunoblastic LymphadenopathyImmunotherapyLymphoma, Non-HodgkinLymphoproliferative DisordersMaleMiddle AgedMultiple MyelomaPeripheral Blood Stem Cell TransplantationRemission InductionTransplantation, AutologousAntineoplastic AgentsAntiviral Agents

Identifiers

PMID12209355
OpenAlexW2005626039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.