ReviewMicrobiology and molecular biology reviews : MMBR2002
Regulation of gene expression by ambient pH in filamentous fungi and yeasts.
Review in Microbiology and molecular biology reviews : MMBR, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 314 citations in OpenAlex.
- Increased production of the important broad-range endolytic protease proteinase K by the fungus Parengyodontium album through adaptation of the growth medium.Bioprocess and biosystems engineering · 2026Article
- From the Ground to the Clinic: The Evolution and Adaptation of Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Article
- Global Stress Responses Identify the Functionally Divergent Regulators Required forExploration (Beijing, China) · 2025Article
- Transcriptional Responses to Alkaline pH Across Fungi: Common and Differential Features, and Biotechnological Applications.International journal of molecular sciences · 2025Review
- Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression inApplied and environmental microbiology · 2025Article
- Cellulase Production by Ultraviolet-Derived MutantInternational journal of molecular sciences · 2025Article
- The pH signaling pathway Pal/PacC regulates fungal growth, stress responses, and mycotoxin biosynthesis in Fusarium graminearum.Crop health · 2025Article
- Unveiling the Role of StuA in Transcription Regulation in Trichophyton rubrum: From Global Regulation Dynamics to the pH-Responsive Program Control.Mycopathologia · 2025Article
- Dynamic Transcription Machineries in Protocells.Journal of the American Chemical Society · 2025Review
- Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025Review
- Global transcription machinery engineering in Yarrowia lipolytica.FEMS yeast research · 2025Review
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH.PLoS biology · 2024Article
- Article
- Combined transcriptomic and metabolomic analysis revealed that pH changes affected the expression of carbohydrate and ribosome biogenesis-related genes inFrontiers in microbiology · 2024Article
- Transcriptome Analysis Reveals the Regulation ofInternational journal of molecular sciences · 2023Article
- Transcription factors enhancing synthesis of recombinant proteins and resistance to stress in Yarrowia lipolytica.Applied microbiology and biotechnology · 2023Article
- Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological Aspects.Journal of fungi (Basel, Switzerland) · 2023Review
- Genetic Regulation of Mycotoxin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2022Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life, as we know it, is water based. Exposure to hydroxonium and hydroxide ions is constant and ubiquitous, and the evolutionary pressure to respond appropriately to these ions is likely to be intense. Fungi respond to their environments by tailoring their output of activities destined for the cell surface or beyond to the ambient pH. We are beginning to glimpse how they sense ambient pH and transmit this information to the transcription factor, whose roles ensure that a suitable collection of gene products will be made. Although relatively little is known about pH signal transduction itself, its consequences for the cognate transcription factor are much clearer. Intriguingly, homologues of components of this system mediating the regulation of fungal gene expression by ambient pH are to be found in the animal kingdom. The potential applied importance of this regulatory system lies in its key role in fungal pathogenicity of animals and plants and in its control of fungal production of toxins, antibiotics, and secreted enzymes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.