ArticleJournal of virology2002
A conserved capsid protein surface domain of Cucumber mosaic virus is essential for efficient aphid vector transmission.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 99 citations in OpenAlex.
- Chalcones as a Versatile Antiviral Scaffold: Molecular Targets, ADMET Profiles, and Translational Challenges.Viruses · 2026Review
- Cucumber Mosaic Virus Coat Protein Sequesters Host CDPK7-Like Into Phase-Separated Condensates to Promote Viral Infection.Molecular plant pathology · 2026Article
- The Amino-Proximal Region of the Coat Protein of Cucumber Vein Yellowing Virus (FamilyPlants (Basel, Switzerland) · 2021Article
- Characterization and evolutionary analysis of Cucumber mosaic virus isolate infecting3 Biotech · 2021Article
- Physical contact transmission of Cucumber green mottle mosaic virus by Myzus persicae.PloS one · 2021Article
- The 2b protein and C-terminal region of the 2a protein indispensably facilitate systemic movement of cucumber mosaic virus in radish with supplementary function by either the 3a or the coat protein.Virology journal · 2020Article
- From a Movement-Deficient Grapevine Fanleaf Virus to the Identification of a New Viral Determinant of Nematode Transmission.Viruses · 2019Article
- Maize chlorotic mottle virus exhibits low divergence between differentiated regional sub-populations.Scientific reports · 2018Article
- Plant Virus-Insect Vector Interactions: Current and Potential Future Research Directions.Viruses · 2016Review
- Quantitative transcriptional changes associated with chlorosis severity in mosaic leaves of tobacco plants infected with Cucumber mosaic virus.Molecular plant pathology · 2014Article
- Cucumber mosaic virus: viral genes as virulence determinants.Molecular plant pathology · 2012Review
- Structural studies on antibody recognition and neutralization of viruses.Current opinion in virology · 2011Review
- Structural insights into viral determinants of nematode mediated Grapevine fanleaf virus transmission.PLoS pathogens · 2011Article
- Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects: implications for the origin of the virus.Journal of virology · 2011Article
- A stretch of 11 amino acids in the betaB-betaC loop of the coat protein of grapevine fanleaf virus is essential for transmission by the nematode Xiphinema index.Journal of virology · 2010Article
- Estimation of the effective number of founders that initiate an infection after aphid transmission of a multipartite plant virus.Journal of virology · 2008Article
- Chemical and genetic wrappers for improved phage and RNA display.Chembiochem : a European journal of chemical biology · 2008Article
- Analysis of genetic bottlenecks during horizontal transmission of Cucumber mosaic virus.Journal of virology · 2006Article
- Compensatory capsid protein mutations in cucumber mosaic virus confer systemic infectivity in squash (Cucurbita pepo).Journal of virology · 2006Article
- Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids.Biopolymers · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prominent feature on the surfaces of virions of Cucumber mosaic virus (CMV) is a negatively charged loop structure (the beta H-beta I loop). Six of 8 amino acids in this capsid protein loop are highly conserved among strains of CMV and other cucumoviruses. Five of these amino acids were individually changed to alanine or lysine (an amino acid of opposite charge) to create nine mutants (the D191A, D191K, D192A, D192K, L194A, E195A, E195K, D197A, and D197K mutants). Transcripts of cDNA clones were infectious when they were mechanically inoculated onto tobacco, giving rise to symptoms of a mottle-mosaic typical of the wild-type virus (the D191A, D191K, D192A, E195A, E195K, and D197A mutants), a systemic necrosis (the D192K mutant), or an atypical chlorosis with necrotic flecking (the L194A mutant). The mutants formed virions and accumulated to wild-type levels, but eight of the nine mutants were defective in aphid vector transmission. The aspartate-to-lysine mutation at position 197 interfered with infection; the only recovered progeny (the D197K(*) mutant) harbored a second-site mutation (denoted by the asterisk) of alanine to glutamate at position 193, a proximal site in the beta H-beta I loop. Since the disruption of charged amino acid residues in the beta H-beta I loop reduces or eliminates vector transmissibility without grossly affecting infectivity or virion formation, we hypothesize that this sequence or structure has been conserved to facilitate aphid vector transmission.
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