ArticleThe Journal of clinical investigation2002
An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Transcription factor c-Jun modulates GLUT1 in glycolysis and breast cancer metastasis.BMC cancer · 2022Article
- Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth.Cell reports · 2020Article
- Review
- Translational reprogramming marks adaptation to asparagine restriction in cancer.Nature cell biology · 2019Article
- Rsu1-dependent control of PTEN expression is regulated via ATF2 and cJun.Journal of cell communication and signaling · 2019Article
- RegulatorTrail: a web service for the identification of key transcriptional regulators.Nucleic acids research · 2017Article
- ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.Pharmacological research · 2017Review
- ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells.Oncology letters · 2016Article
- Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.Nature communications · 2016Article
- A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.Cell reports · 2016Article
- Activating transcription factor 2 expression mediates cell proliferation and is associated with poor prognosis in human non-small cell lung carcinoma.Oncology letters · 2016Article
- The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis.Journal of biomedical science · 2015Article
- Bim and VDAC1 are hierarchically essential for mitochondrial ATF2 mediated cell death.Cancer cell international · 2015Article
- LXXLL peptide converts transportan 10 to a potent inducer of apoptosis in breast cancer cells.International journal of molecular sciences · 2014Article
- ATF2 knockdown reinforces oxidative stress-induced apoptosis in TE7 cancer cells.Journal of cellular and molecular medicine · 2013Article
- Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Melanoma: from mutations to medicine.Genes & development · 2012Review
- Article
- Activating transcription factor-2 in survival mechanisms in head and neck carcinoma cells.Head & neck · 2011Article
- Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma.Chinese medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Melanomas are among the aggressive tumor types because of their notorious resistance to treatment and their high capacity to metastasize. ATF2 is among transcription factors implicated in the progression of melanoma and its resistance to treatment. Here we demonstrate that the expression of a peptide spanning amino acids 50-100 of ATF2 (ATF2(50-100)) reduces ATF2 transcriptional activities while increasing the expression and activity of c-Jun. Altering the balance of Jun/ATF2 transcriptional activities sensitized melanoma cells to apoptosis, an effect that could be attenuated by inhibiting c-Jun. Inhibition of ATF2 via RNA interference likewise increased c-Jun expression and primed melanoma cells to undergo apoptosis. Growth and metastasis of SW1 and B16F10 mouse melanomas were inhibited by ATF2(50-100) to varying degrees up to a complete regression, depending on the mode (inducible, constitutive, or adenoviral delivery) of its expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.