ArticleGenes & development2002
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 164 citations in OpenAlex.
- GCL pruning of PIP3 establishes the soma-germline boundary.The Journal of cell biology · 2026Article
- The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling inFrontiers in endocrinology · 2026Article
- Article
- miR-137 targets Myc to regulate growth during eye development.Development (Cambridge, England) · 2025Article
- A feed-forward loop between Toll/NF-κB and Rac1 promotes epithelial to mesenchymal transition of Ras-oncogenic hindgut enterocytes in Drosophila.Biology open · 2025Article
- Ribosome stalling duringPNAS nexus · 2024Article
- The evolution of larger size in high-altitude Drosophila melanogaster has a variable genetic architecture.G3 (Bethesda, Md.) · 2022Article
- OncogenicScience advances · 2021Article
- Review
- Review
- Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.PLoS genetics · 2020Article
- Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth.Nature communications · 2020Article
- Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth.Seminars in cancer biology · 2020Review
- The miRNALife science alliance · 2019Article
- Harnessing epithelial homeostatic mechanisms to fight cancer.Molecular biology of the cell · 2019Article
- Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation.Current biology : CB · 2019Article
- Article
- Article
- Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis.Nature communications · 2018Article
- Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila.PLoS genetics · 2018Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Ras GTPase links extracellular signals to intracellular mechanisms that control cell growth, the cell cycle, and cell identity. An activated form of Drosophila Ras (Ras(V12)) promotes these processes in the developing wing, but the effector pathways involved are unclear. Here, we present evidence indicating that Ras(V12) promotes cell growth and G(1)/S progression by increasing dMyc protein levels and activating dPI3K signaling, and that it does so via separate effector pathways. We also show that endogenous Ras is required to maintain normal levels of dMyc, but not dPI3K signaling during wing development. Finally, we show that induction of dMyc and regulation of cell identity are separable effects of Raf/MAPK signaling. These results suggest that Ras may only affect PI3K signaling when mutationally activated, such as in Ras(V12)-transformed cells, and provide a basis for understanding the synergy between Ras and other growth-promoting oncogenes in cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.