ArticleBritish journal of pharmacology2002
Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 212 citations in OpenAlex.
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- Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat.The Korean journal of pain · 2022Article
- Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats.Communications biology · 2022Article
- Dezocine as a potent analgesic: overview of its pharmacological characterization.Acta pharmacologica Sinica · 2022Review
- Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy.Neurotoxicity research · 2022Review
- Activation of Hypocretin Neurons in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- An overview of the orexinergic system in different animal species.Metabolic brain disease · 2021Review
- Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice.Scientific reports · 2021Article
- Orexin receptors in GtoPdb v.2021.3.IUPHAR/BPS guide to pharmacology CITE · 2021Article
- Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice.Journal of neuroinflammation · 2020Article
- Significant Quantitative Differences in Orexin Neuronal Activation After Pain Assessments in an Animal Model of Sickle Cell Disease.Frontiers in molecular biosciences · 2020Article
- The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Orexin-A and orexin-B (also known as hypocretin-1 and hypocretin-2) are hypothalamic peptides and regulate feeding behaviour, energy metabolism and the sleep-wake cycle. Orexin-A binds equally to both orexin-1 and orexin-2 receptors, while orexin-B has a preferential affinity for orexin-2 receptors. 2. Orexins are also known to be concentrated in superficial laminae of the spinal dorsal horn, and orexin-A and orexin-1 receptors are found in the dorsal root ganglion cells. 3. In the present study, the authors examined the effect of intrathecal injection of either orexin-A or orexin-B in the rat formalin test (a model of inflammatory pain) and in the rat hot plate test. The paw formalin injection induces biphasic flinching (phase 1: 0-6 min; phase 2: 10-60 min) of the injected paw. 4. Intrathecal injection of orexin-A, but not orexin-B, decreased the sum of flinches in phases 1 and 2 in the formalin test and increased the hot plate latency. These effects of orexin-A were completely antagonized by pre-treatment with SB-334867, a selective orexin-1 receptor antagonist. Intrathecal injection of SB-334867 alone had no effect in the formalin test or in the hot plate test. 5. Intrathecal injection of orexin-A suppressed the expression of Fos-like immunoreactivity (Fos-LI), induced by paw formalin injection, in laminae I-II of L4-5 of the spinal cord. 6. These data suggest that the spinal orexin-1 receptor is involved in the nociceptive transmission and that the activation of the spinal orexin-1 receptor produces analgesic effects in the rat formalin test and in the rat hot plate test.
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