ArticleBritish journal of pharmacology2002
Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Cardiovascular β-Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue.Comprehensive Physiology · 2026Review
- Oestrogen receptors regulate vascular β₁- and β₃-adrenoceptor expression and shape sex-specific adrenergic control of vascular tone.Pflugers Archiv : European journal of physiology · 2026Article
- Immune and Metabolic Mechanisms of Endothelial Dysfunction.International journal of molecular sciences · 2024Review
- Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aortaTurkish journal of medical sciences · 2021Article
- Involvement of Gi protein-dependent BKNaunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Cardiac βBritish journal of pharmacology · 2019Review
- Autonomic Receptors and Nitric-Oxide Involvements in Mediating Vasorelaxation Effect Induced byPharmacognosy research · 2017Article
- Role of βInternational journal of clinical and experimental pathology · 2017Article
- Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of KBMC anesthesiology · 2016Article
- Adenosine relaxation in isolated rat aortic rings and possible roles of smooth muscle Kv channels, KATP channels and A2a receptors.BMC pharmacology & toxicology · 2016Article
- Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.British journal of pharmacology · 2013Article
- The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist.PloS one · 2013Article
- Article
- β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.PloS one · 2012Article
- Adrenergic mechanism in the control of endothelial function.Translational medicine @ UniSa · 2011Article
- β(3) Receptors: Role in Cardiometabolic Disorders.Therapeutic advances in endocrinology and metabolism · 2011Article
- Morphine-mediated alteration of hypertension-related gene expression in human white blood cells and multilineage progenitor cells.Journal of human hypertension · 2010Article
- Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system.Journal of molecular and cellular cardiology · 2010Review
- beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- Mixed beta3-adrenoceptor agonist and alpha1-adrenoceptor antagonist properties of nebivolol in rat thoracic aorta.British journal of pharmacology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We have previously demonstrated that beta(3)-adrenoceptor (beta(3)-AR) stimulation induces endothelium-dependent vasorelaxation in rat aorta through the activation of an endothelial NO synthase associated with an increase in intracellular cGMP. The aim of the present study was to localise beta(3)-AR to confirm our functional study and to complete the signalling pathway of beta(3)-AR in rat aorta. 2. By RT-PCR, we have detected beta(3)-AR transcripts both in aorta and in freshly isolated endothelial cells. The absence of markers for adipsin or hormone-sensitive lipase in endothelial cells excluded the presence of beta(3)-AR from adipocytes. The localization of beta(3)-AR in aortic endothelial cells was confirmed by immunohistochemistry using a rat beta(3)-AR antibody. 3. To identify the G protein linked to beta(3)-AR, experiments were performed in rat pre-treated with PTX (10 microg kg(-1)), a G(i/0) protein inhibitor. The blockage of G(i/0) protein by PTX was confirmed by the reduction of vasorelaxation induced by UK 14304, a selective alpha(2)-AR agonist. The cumulative concentration-response curve for SR 58611A, a beta(3)-AR agonist, was not significantly modified on aorta rings from PTX pre-treated rats. 4. At the same level of contraction, the relaxations induced by 10 microM SR 58611A were significantly reduced in 30 mM-KCl pre-constricted rings (E(max)=16.7+/-8.4%, n=5), in comparison to phenylephrine (0.3 microM) pre-constricted rings (E(max)=49.11+/-11.0%, n=5, P<0.05). In addition, iberotoxin (0.1 microM), glibenclamide (1 microM) and 4-aminopyridine (1 mM), selective potassium channels blockers of K(Ca), K(ATP), and K(v) respectively, decreased the SR 58611A-mediated relaxation. 5. We conclude that beta(3)-AR is preferentially expressed in rat aortic endothelial cells. Beta(3)-AR-mediated aortic relaxation is independent of G(i/0) proteins stimulation, but results from the activation of several potassium channels, K(Ca), K(ATP), and K(v).
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