ArticleThe Biochemical journal2002
Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner.Cell death & disease · 2025Article
- Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling.Frontiers in cell and developmental biology · 2024Article
- Protein Kinase C Life Cycle: Explained Through Systems Biology Approach.Frontiers in physiology · 2022Article
- Involvement of Protein Kinase D1 in Signal Transduction from the Protein Kinase C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-releasing Hormone.The Journal of biological chemistry · 2015Article
- Transformer 2β homolog (Drosophila) (TRA2B) regulates protein kinase C δI (PKCδI) splice variant expression during 3T3L1 preadipocyte cell cycle.The Journal of biological chemistry · 2014Article
- Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.Neuromolecular medicine · 2014Article
- Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.The Journal of biological chemistry · 2013Article
- Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism.The Journal of biological chemistry · 2013Article
- Molecular mechanisms of mouse skin tumor promotion.Cancers · 2010Article
- Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.Cellular signalling · 2009Article
- Degradation of activated protein kinases by ubiquitination.Annual review of biochemistry · 2009Review
- The life and death of protein kinase C.Current drug targets · 2008Review
- The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta.The Biochemical journal · 2006Article
- Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.Oncogene · 2006Article
- Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta.Circulation research · 2005Article
- PKC controls HGF-dependent c-Met traffic, signalling and cell migration.The EMBO journal · 2004Article
- Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex.Molecular and cellular biology · 2004Article
- Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.Molecular biology of the cell · 2004Article
- Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.The Journal of cell biology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical and novel protein kinase C (PKC) isoforms are down-regulated as a result of chronic activation by certain tumour promoters and physiological stimuli; however, the mechanisms leading to down-regulation are not fully understood. In the present study, we have studied the PMA ('TPA')-induced degradation of PKCdelta in NIH 3T3 cells under culture conditions where PKCdelta displays cell-cycle-dependent down-regulation. In contrast with previous studies, a hyperphosphorylated form of this PKC isoform, promoted by calyculin A, was rapidly degraded in PMA-treated cells. Similarly, the presence of calyculin A enhanced the down-regulation of PKCdelta observed on G(1)/S-phase progression through the cell cycle. Analysis of phosphorylation-site mutants indicated that the T-loop Thr(505) phosphorylation site was critical for induced degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.