ArticleAgents and actions1975
Irritancy of cyclophosphamide-derived aldehydes (acrolein, chloracetaldehyde) and their effect on lymphocyte distribution in vivo: protective effect of thiols and bisulphite ions1).
Article in Agents and actions, 1975. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 18 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) A strategy is described for investigating agents such as N-acetylcysteine or penicillamine that might be used as adjuvant therapy with cyclophosphamide, to lessen the toxic side-effects of this latter drug caused by some of its metabolites. (2) The toxic effects of acrolein and chloracetaldehyde were determined by (a) their effects on lymphocyte circulation and (b) their oedemagenic activity in rats. (3) Stable thiols and bisulphite ions antagonised this aldehyde toxicity/irritancy; thiosulphate ions did not. (4) Thiosulphate and bisulphite ions antagonised the irritancy/toxicity of a mustard, mechlorethamine (HN-2). (5) The possible relationship of intrinsic irritancy to anti-inflammatory activity is discussed briefly.
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