ArticleProceedings of the National Academy of Sciences of the United States of America2002
Genomic profiles of clinical and environmental isolates of Vibrio cholerae O1 in cholera-endemic areas of Bangladesh.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Prevalence and antimicrobial susceptibility pattern of Vibrio cholerae isolates from cholera outbreak sites in Ethiopia.BMC public health · 2024Article
- Temporal trend and spatial clustering of cholera epidemic in Kumasi-Ghana.Scientific reports · 2018Article
- Identifying environmental risk factors of cholera in a coastal area with geospatial technologies.International journal of environmental research and public health · 2014Article
- Amplified fragment length polymorphism of clinical and environmental Vibrio cholerae from a freshwater environment in a cholera-endemic area, India.BMC infectious diseases · 2011Article
- Whole genome PCR scanning reveals the syntenic genome structure of toxigenic Vibrio cholerae strains in the O1/O139 population.PloS one · 2011Article
- Association of Heavy Rainfall on Genotypic Diversity in V. cholerae Isolates from an Outbreak in India.International journal of microbiology · 2011Article
- Biogeographic patterns in genomic diversity among a large collection of Vibrio cholerae isolates.Applied and environmental microbiology · 2009Article
- Diversity and seasonality of bioluminescent Vibrio cholerae populations in Chesapeake Bay.Applied and environmental microbiology · 2009Article
- Determination of clonality and relatedness of Vibrio cholerae isolates by genomic fingerprinting, using long-range repetitive element sequence-based PCR.Applied and environmental microbiology · 2008Article
- The role of prophage for genome diversification within a clonal lineage of Lactobacillus johnsonii: characterization of the defective prophage LJ771.Journal of bacteriology · 2008Article
- Seasonality of cholera from 1974 to 2005: a review of global patterns.International journal of health geographics · 2008Article
- Serogroup conversion of Vibrio cholerae in aquatic reservoirs.PLoS pathogens · 2007Article
- Detection and transformation of genome segments that differ within a coastal population of Vibrio cholerae strains.Applied and environmental microbiology · 2007Article
- Vibrio cholerae strain typing and phylogeny study based on simple sequence repeats.Journal of clinical microbiology · 2007Article
- Inference for nonlinear dynamical systems.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Biofilm formation and phenotypic variation enhance predation-driven persistence of Vibrio cholerae.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Pathogen adaptation to seasonal forcing and climate change.Proceedings. Biological sciences · 2005Article
- A glimpse into the expanded genome content of Vibrio cholerae through identification of genes present in environmental strains.Journal of bacteriology · 2005Article
- Biodiversity of vibrios.Microbiology and molecular biology reviews : MMBR · 2004Review
- Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Abstract
Diversity, relatedness, and ecological interactions of toxigenic Vibrio cholerae O1 populations in two distinctive habitats, the human intestine and the aquatic environment, were analyzed. Twenty environmental isolates and 42 clinical isolates were selected for study by matching serotype, geographic location of isolation in Bangladesh, and season of isolation. Genetic profiling was done by enterobacterial repetitive intergenic consensus sequence-PCR, optimized for profiling by using the fully sequenced V. cholerae El Tor N16961 genome. Five significant clonal clusters of haplotypes were found from 57 electrophoretic types. Isolates from different areas or habitats intermingled in two of the five significant clusters. Frequencies of haplotypes differed significantly only between the environmental populations (exact test; P < 0.05). Analysis of molecular variance yielded a population genetic structure reflecting the differentiating effects of geographic area, habitat, and sampling time. Although a parameter confounding the latter differences explained 9% of the total molecular variance in the entire population (P < 0.01), the net effect of habitat and time could not be separated because of the small number of environmental isolates included in the study. Five subpopulations from a single area were determined, and from these we were able to estimate a relative differentiating effect of habitat, which was small compared with the effect of temporal change. In conclusion, the resulting population structure supports the hypothesis that spatial and temporal fluctuations in the composition of toxigenic V. cholerae populations in the aquatic environment can cause shifts in the dynamics of the disease.
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