ArticleThe Journal of physiology2002
Adrenergic signalling between rat taste receptor cells.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- β2-Adrenergic Receptor Utilizes Distinct Interaction Interfaces to Selectively form Heterooligomers with a Subset of Bitter Taste Receptors.Biochemistry · 2025Article
- Article
- Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation.European journal of histochemistry : EJH · 2022Article
- Fatigue, Stress, and Functional Status are Associated With Taste Changes in Oncology Patients Receiving Chemotherapy.Journal of pain and symptom management · 2021Article
- Chemical and electrical synaptic interactions among taste bud cells.Current opinion in physiology · 2021Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (Frontiers in systems neuroscience · 2017Article
- Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells.Pflugers Archiv : European journal of physiology · 2016Article
- Taste buds as peripheral chemosensory processors.Seminars in cell & developmental biology · 2013Review
- Adenosine enhances sweet taste through A2B receptors in the taste bud.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Characterization of the expression pattern of adrenergic receptors in rat taste buds.Neuroscience · 2010Article
- Type II and III Taste Bud Cells Preferentially Expressed Kainate Glutamate Receptors in Rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2009Article
- Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells.The Journal of physiology · 2009Article
- GABA expression in the mammalian taste bud functions as a route of inhibitory cell-to-cell communication.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Norepinephrine is coreleased with serotonin in mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Functional expression of ionotropic purinergic receptors on mouse taste bud cells.The Journal of physiology · 2007Article
- Human taste thresholds are modulated by serotonin and noradrenaline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Separate populations of receptor cells and presynaptic cells in mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In taste buds, synaptic transmission is traditionally thought to occur from taste receptor cells to the afferent nerve. This communication reports the novel observation that taste receptor cells respond to adrenergic stimulation. Noradrenaline application inhibited outward potassium currents in a dose-dependent manner. This inhibition was mimicked by the beta agonist isoproterenol and blocked by the beta antagonist propranolol. The alpha agonists clonidine and phenylephrine both inhibited the potassium currents and elevated intracellular calcium levels. Inwardly rectifying potassium currents were unaffected by adrenergic stimulation. Experiments using the RT-PCR technique demonstrate that lingual epithelium expresses multiple alpha (alpha1a, alpha1b, alpha1c, alpha1d, alpha2a, alpha2b, alpha2c) and beta (beta1, beta2) subtypes of adrenergic receptors, and immunocytochemistry localized noradrenaline to a subset of taste receptor cells. Collectively, these data imply strongly that adrenergic transmission within the taste bud may play a paracrine role in taste physiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.