ArticleJournal of medical genetics2002
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.
Article in Journal of medical genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Pamidronate Down-regulates Tumor Necrosis Factor-alpha Induced Matrix Metalloproteinases Expression in Human Intervertebral Disc Cells.Journal of bone metabolism · 2016Article
- Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.Oncotarget · 2016Article
- PRDM14 promotes the migration of human non-small cell lung cancer through extracellular matrix degradation in vitro.Chinese medical journal · 2015Article
- Combining mouse mammary gland gene expression and comparative mapping for the identification of candidate genes for QTL of milk production traits in cattle.BMC genomics · 2007Article
- Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.The American journal of pathology · 2005Article
- The landscape of genetic complexity across 5,700 gene expression traits in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis.Journal of medical genetics · 2003Article
- A high performance test of differential gene expression for oligonucleotide arrays.Genome biology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We applied microarray gene expression profiling to lungs from mouse strains having variable susceptibility to lung tumour development as a means to identify, within known quantitative trait loci (QTLs), candidate genes responsible for susceptibility or resistance to lung cancer. At least eight chromosomal regions of mice have been mapped and verified to be linked with lung tumour susceptibility or resistance. In this study, high density oligonucleotide arrays were used to measure the relative expression levels of >36 000 genes and ESTs in lung tissues of A/J, BALB/cJ, SM/J, C3H/HeJ, and C57BL/6J mice. A number of differentially expressed genes were found in each of the lung cancer susceptibility QTLs. Bioinformatic analysis of the differentially expressed genes located within QTLs produced 28 susceptibility candidates and 22 resistance candidates. These candidates may be extremely helpful in the ultimate identification of the precise genes responsible for lung tumour susceptibility or resistance in mice and, through follow up, humans. Complete data sets are available at http://thinker.med.ohio-state.edu.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.