ReviewJournal of medical genetics2002
Hereditary paraganglioma targets diverse paraganglia.
Review in Journal of medical genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 233 citations in OpenAlex.
- Surgical resection versus stereotactic radiosurgery for succinate dehydrogenase-related hereditary head and neck paragangliomas.Journal of neuro-oncology · 2026Article
- Pheochromocytomas and Paragangliomas-Current Management.Cancers · 2025Review
- Non Functioning Vagal Paraganglioma in the Infrahyoid Neck: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Identification of a pathogenic SDHD mutation in a Chinese family with hereditary head and neck paraganglioma: implications for genetic counseling and management.World journal of surgical oncology · 2025Article
- Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10FASEB bioAdvances · 2024Article
- Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck.Cancer medicine · 2024Article
- Article
- Primary Functioning Hepatic Paraganglioma Treated by Laparoscopy: A Case Report.Journal of clinical medicine · 2022Article
- Multiparametric ultrasound evaluation of a case of bilateral carotid body tumor.Journal of ultrasound · 2021Article
- Diaphragmatic Paraganglioma in an Adolescent Male.Cureus · 2021Article
- Metastatic Paraganglioma of the Spine WithInternational journal of spine surgery · 2021Article
- Head and neck paragangliomas: 30-year experience.Head & neck · 2020Article
- Pheochromocytoma and paraganglioma: implications of germline mutation investigation for treatment, screening, and surveillance.Archives of endocrinology and metabolism · 2019Article
- A Clinical Efficacy of PRRT in Patients with Advanced, Nonresectable, Paraganglioma-Pheochromocytoma, Related to SDHx Gene Mutation.Journal of clinical medicine · 2019Article
- COPPS, a composite score integrating pathological features, PS100 and SDHB losses, predicts the risk of metastasis and progression-free survival in pheochromocytomas/paragangliomas.Virchows Archiv : an international journal of pathology · 2019Article
- [Surgical treatment options for cervical paragangliomas].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Review
- Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.PloS one · 2019Article
- Thyroid paraganglioma: a case series of a rare head and neck tumor.Journal of surgical case reports · 2018Article
- The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS.The Journal of biological chemistry · 2018Article
- Jugulotympanic paragangliomas in southern Finland: a 40-year experience suggests individualized surgical management.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paragangliomas are highly vascularised and often heritable tumours derived from paraganglia, a diffuse neuroendocrine system dispersed from skull base to the pelvic floor. The carotid body, a small oxygen sensing organ located at the bifurcation of the carotid artery in the head and neck and the adrenal medulla in the abdomen, are the most common tumour sites. It now appears that mutations in SDHB, SDHC, and SDHD, which encode subunits of mitochondrial complex II (succinate dehydrogenase; succinate-ubiquinone oxidoreductase), are responsible for the majority of familial paragangliomas and also for a significant fraction of non-familial tumours. Germline mutations in complex II genes are associated with the development of paragangliomas in diverse anatomical locations, including phaeochromocytomas, a finding that has important implications for the clinical management of patients and genetic counselling of families. Consequently, patients with a paraganglioma tumour, including phaeochromocytoma, and a complex II germline mutation should be diagnosed with hereditary paraganglioma, regardless of family history, anatomical location, or multiplicity of tumours. This short review attempts to bring together relevant genetic data on paragangliomas with a particular emphasis on head and neck paragangliomas and phaeochromocytomas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.