ArticleClinical and diagnostic laboratory immunology2002
Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection.
Article in Clinical and diagnostic laboratory immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 127 citations in OpenAlex.
- Real-world evidence of a novel tetravalent immunoglobulin Y effectiveness and safety in patients with the refractory Helicobacter pylori infection.BMC infectious diseases · 2024Trial
- Bovine antibody-based oral immunotherapy for reduction of intragastric Helicobacter pylori colonization: a randomized clinical trial.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Trial
- Efficacy of IgY onAntibody therapeutics · 2026Article
- Immunoglobulin Y protects intestinal epithelium and modulates gut microbiota.Microbiome research reports · 2026Article
- Therapeutic suppression ofFrontiers in microbiology · 2026Article
- Evaluation of the prevention, treatment and synergistic activity betweenIranian journal of microbiology · 2025Article
- Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.Gut pathogens · 2025Review
- Passive Immunotherapy of Cynomolgus Monkeys with Anti-Rotavirus IgY.Pharmaceutics · 2024Article
- Characterization of anti-soybean agglutinin (SBA) IgY antibodies: a new strategy for neutralization of the detrimental biological activity of SBA.Frontiers in veterinary science · 2024Article
- IgY antibodies: The promising potential to overcome antibiotic resistance.Frontiers in immunology · 2023Review
- IgYs: on her majesty's secret service.Frontiers in immunology · 2023Review
- Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases.Frontiers in immunology · 2021Review
- Development of Adenosine Deaminase-Specific IgY Antibodies: Diagnostic and Inhibitory Application.Applied biochemistry and biotechnology · 2018Article
- Neisseria flavescens: A Urease-Expressing Potential Pathogen Isolated from Gastritis Patients.Current microbiology · 2018Article
- Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Article
- Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review.Korean journal for food science of animal resources · 2017Article
- A review on detection methods used for foodborne pathogens.The Indian journal of medical research · 2016Review
- IgY antibodies in human nutrition for disease prevention.Nutrition journal · 2015Review
- Production of specific IgY Helicobacter pylori recombinant OipA protein and assessment of its inhibitory effects towards attachment of H. pylori to AGS cell line.Clinical and experimental vaccine research · 2015Article
- Therapeutic and prevention strategies against human enterovirus 71 infection.World journal of virology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluated the potential use of immunoglobulin prepared from the egg yolk of hens immunized with Helicobacter pylori (immunoglobulin Y [IgY]-Hp) in the treatment of H. pylori infections. The purity of our purified IgY-Hp was 91.3%, with a yield of 9.4 mg of IgY per ml of egg yolk. The titer for IgY-Hp was 16 times higher than that for IgY in egg yolk from nonimmunized hens, and IgY-Hp significantly inhibited the growth and urease activity of H. pylori in vitro. Bacterial adhesion on AGS cells was definitely reduced by preincubation of both H. pylori (10(8) CFU/ml) and 10 mg of IgY-Hp/ml. In Mongolian gerbil models, IgY-Hp decreased H. pylori-induced gastric mucosal injury as determined by the degree of lymphocyte and neutrophil infiltration. Therefore, in this experimental model, H. pylori-associated gastritis could be successfully treated by orally administered IgY-Hp. The immunological activity of IgY-Hp stayed active at 60 degrees C for 10 min, suggesting that pasteurization can be applied to sterilize the product. Fortification of food products with this immunoglobulin would significantly decrease the H. pylori infection. In conclusion, the IgY-Hp obtained from hens immunized by H. pylori could provide a novel alternative approach to treatment of H. pylori infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.