Trial reportHuman brain mapping2002
Carpal tunnel syndrome modifies sensory hand cortical somatotopy: a MEG study.
Trial report in Human brain mapping, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.
- Altered brain function and structure in carpal tunnel syndrome: a systematic review and meta-analysis of structural and functional brain imaging.Brain structure & function · 2024Pooled it
- Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.Brain : a journal of neurology · 2017Trial
- A randomized sham-controlled trial of a neurodynamic technique in the treatment of carpal tunnel syndrome.The Journal of orthopaedic and sports physical therapy · 2009Trial
- Cerebral Changes Following Carpal Tunnel Syndrome Treated with Guided Plasticity: A Prospective, Randomized, Placebo-Controlled Study.Journal of brachial plexus and peripheral nerve injury · 2024Article
- Feasibility and usability of a virtual-reality-based sensorimotor activation apparatus for carpal tunnel syndrome patients.PloS one · 2023Article
- Altered bodily perceptions in chronic neuropathic pain conditions and implications for treatment using immersive virtual reality.Frontiers in human neuroscience · 2022Review
- Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity.Brain communications · 2022Article
- [Entrapment neuropathies: a contemporary approach to pathophysiology, clinical assessment, and management : German version].Schmerz (Berlin, Germany) · 2021Review
- Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation.Journal of pain research · 2021Review
- Understanding central sensitization for advances in management of carpal tunnel syndrome.F1000Research · 2020Review
- Prevalence of carpal tunnel syndrome presenting with symptoms in an ulnar nerve distribution: A prospective study.Muscle & nerve · 2019Article
- Mapping the topological organisation of beta oscillations in motor cortex using MEG.NeuroImage · 2018Article
- Brain remodeling after chronic median nerve compression in a rat model.Neural regeneration research · 2018Article
- Carpal tunnel syndrome impairs index finger responses to unpredictable perturbations.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2018Article
- Reduced insula habituation associated with amplification of trigeminal brainstem input in migraine.Cephalalgia : an international journal of headache · 2017Article
- Using visuo-kinetic virtual reality to induce illusory spinal movement: the MoOVi Illusion.PeerJ · 2017Article
- Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome.PloS one · 2017Article
- Viewing the body modulates both pain sensations and pain responses.Experimental brain research · 2016Article
- Combined Cubital and Carpal Tunnel Release Results in Symptom Resolution Outside of the Median or Ulnar Nerve Distributions.The open orthopaedics journal · 2016Article
- Restoring tactile and proprioceptive sensation through a brain interface.Neurobiology of disease · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult somatosensory system has shown reorganizational abilities at cortical and subcortical levels after peripheral nerve lesions. In the present study the effects of carpal tunnel syndrome (CTS) are investigated as reflected on the somatotopy of the primary cortical hand representation. Position and intensity of cortical sources activated by the separate electrical stimulation of median nerve and Digits 1, 3, and 5 of both affected and non-affected hands are evaluated by magnetoencephalographic (MEG) technique. Correlation of MEG results with patient-, physician- and neurophysiological-oriented evaluations of CTS was carried out. Patients showed changes in cortical hand somatotopy in strict relationship to self-referred assessment of symptoms and hand disability in daily activities, including: 1) a more extended representation of the affected hand when paresthesias prevailed; and 2) a more restricted representation due to lateral shift of the little finger was observed when pain symptoms dominated the clinical picture. Contralateral to the side of CTS, the cortical sources activated by Digit 5-stimulation appeared significantly enhanced with respect to contralateral ones from non-affected hand. When comparing the amplitude of peripheral sensory nerve action potentials of median and ulnar nerves to that of cortical responses (i.e., ECD strengths of M20 and M30 components after stimulation of Digits 3 and 5), a significant selective amplification of M30 with respect to M20 and sensory nerve action potential (SNAP) appeared during Digit 3 stimulation compared to that observed for Digit 5. This has been interpreted as a central magnification mechanism in brain responsiveness, possibly revealing a safety factor enabling sensory perception despite the small peripheral signal due to nerve trunk dysfunction. Hum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.