ArticleJournal of clinical microbiology2002
Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- IFN-γ-Driven macrophage responses in the immunity toFrontiers in cellular and infection microbiology · 2025Review
- The TbD1 Locus Mediates a Hypoxia-Induced Copper Response inFrontiers in microbiology · 2022Article
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- A bug's life in the granuloma.Seminars in immunopathology · 2016Review
- Epigenetic regulation of the nitrosative stress response and intracellular macrophage survival by extraintestinal pathogenic Escherichia coli.Molecular microbiology · 2012Article
- The response of mycobacterium tuberculosis to reactive oxygen and nitrogen species.Frontiers in microbiology · 2011Article
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- Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival.PLoS pathogens · 2010Article
- Conditioning of uropathogenic Escherichia coli for enhanced colonization of host.Infection and immunity · 2009Article
- Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria.Journal of bacteriology · 2009Article
- Polyamine-mediated resistance of uropathogenic Escherichia coli to nitrosative stress.Journal of bacteriology · 2006Article
- Low concentrations of nitric oxide exert a hormetic effect on Mycobacterium tuberculosis in vitro.Journal of clinical microbiology · 2005Article
- Study on myeloperoxidase role in antituberculous defense in the context of cytokine activation.Inflammation · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Susceptibility of six isolates of Mycobacterium tuberculosis (CB3.3, CDC1551, RJ2E, C.C.13, H37Rv, and H37Ra) and two isolates of Mycobacterium bovis (Ravenel and BCG) to reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) was determined by standard in vitro survival assays. After 21 days of incubation, the survival of most strains exposed to either acidified sodium nitrite (ASN) or hydrogen peroxide (H(2)O(2)) was significantly lower than the same strains unexposed to these RNI or ROI products. However, after 50 days of incubation, these differences in susceptibility became less apparent for strains exposed to ASN but not for strains exposed to H(2)O(2). The recovery of these strains after exposure to RNI suggests that the effect of RNI on M. tuberculosis is bacteriostatic. The in vitro concentrations of ROI and RNI used in these assays were higher than those expected in vivo. These observations suggest that, in vivo, RNI expression at physiologically achievable concentrations may keep M. tuberculosis from proliferating but that removal of RNI may allow the organisms to proliferate. Furthermore, the ability of some M. tuberculosis strains to cause rapidly progressive disease may relate to their intrinsic levels of RNI and ROI resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.