ArticleJournal of clinical microbiology2002
Cavitary pneumonia in an AIDS patient caused by an unusual Bordetella bronchiseptica variant producing reduced amounts of pertactin and other major antigens.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- ZoonoticEmerging microbes & infections · 2026Article
- Usefulness of business intelligence to guide antimicrobial treatment decision in infections by infrequent microorganism such asRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Article
- Investigation of the Correlation Between ELISA and Serum Amyloid A in the Diagnosis of Bordetella bronchiseptica in Dogs.Veterinary medicine and science · 2025Article
- Zoonotic Bacterial Respiratory Infections Associated With Cats and Dogs: A Case Series and Literature Review.Cureus · 2022Article
- Characterisation ofEpidemiology and infection · 2020Article
- Chronic cough and cystic lung disease caused byBMJ case reports · 2019Article
- Characterisation of a newly detected bacteriophage infecting Bordetella bronchiseptica in swine.Archives of virology · 2019Article
- Bordetella bronchiseptica pneumonia in a patient with lung cancer; a case report of a rare infection.BMC infectious diseases · 2017Article
- Bordetella bronchiseptica in the immunosuppressed population - a case series and review.Mediterranean journal of hematology and infectious diseases · 2014Article
- Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma.Journal of neuro-oncology · 2011Article
- Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report.Journal of medical case reports · 2009Article
- Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.PloS one · 2009Article
- Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.Clinical microbiology reviews · 2005Review
- External quality assessment for molecular detection of Bordetella pertussis in European laboratories.Journal of clinical microbiology · 2005Article
- Evaluation of real-time PCR for detection of and discrimination between Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii for clinical diagnosis.Journal of clinical microbiology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Bordetella bronchiseptica can infect and colonize immunocompromised humans, its role as a primary pathogen in pneumonia and other respiratory processes affecting those patients remains controversial. A case of cavitary pneumonia caused by B. bronchiseptica in an AIDS patient is presented, and the basis of the seemingly enhanced pathogenic potential of this isolate (designated 814) is investigated. B. bronchiseptica was the only microorganism recovered from sputum, bronchoalveolar lavage fluid, and samples taken through the protected brush catheter. Unlike previous work reporting the involvement of B. bronchiseptica in cases of pneumonia, antibiotic treatment selected on the basis of in vitro antibacterial activity resulted in clearance of the infection and resolution of the pulmonary infiltrate. Although isolate 814 produced reduced amounts of several major antigens including at least one Bvg-activated factor (pertactin), the molecular basis of this deficiency was found to be BvgAS independent since the defect persisted after the bvgAS locus of isolate 814 was replaced with a wild-type bvgAS allele. Despite its prominent phenotype, isolate 814 displayed only a modest yet a significant deficiency in its ability to colonize the respiratory tracts of immunocompetent rats at an early time point. Interestingly, the antibody response elicited by isolate 814 in these animals was almost undetectable. We propose that isolate 814 may be more virulent in immunocompromised patients due, at least in part, to its innate ability to produce low amounts of immunogenic factors which may be required at only normal levels for the interaction of this pathogen with its immunocompetent natural hosts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.