ArticleBiophysical journal2002
Lactosylceramide: effect of acyl chain structure on phase behavior and molecular packing.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Influence of molecular shape and hydrogen bonding on glycolipid self-assembly into thermotropic gyroid phases.Chemical science · 2026Article
- Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Glycosphingolipid and Glycosylphosphatidylinositol Affect Each Other in and on the Cell.Chembiochem : a European journal of chemical biology · 2023Review
- Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers.Biophysical journal · 2022Article
- Lactosylceramide-enriched microdomains mediate human neutrophil immunological functions via carbohydrate-carbohydrate interaction.Glycoconjugate journal · 2022Review
- Membrane Adhesion via Glycolipids Occurs for Abundant Saccharide Chemistries.Biophysical journal · 2020Article
- Headgroup-Ordered Monolayers of Uncharged Glycolipids Exhibit Selective Interactions with Ions.The journal of physical chemistry letters · 2019Article
- The many faces (and phases) of ceramide and sphingomyelin II - binary mixtures.Biophysical reviews · 2017Review
- A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation.Human molecular genetics · 2014Article
- Implications for the mammalian sialidases in the physiopathology of skeletal muscle.Skeletal muscle · 2012Article
- Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils.Glycoconjugate journal · 2008Article
- Using monomolecular films to characterize lipid lateral interactions.Methods in molecular biology (Clifton, N.J.) · 2007Article
- The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.PLoS biology · 2006Article
- Lactosylceramide: lateral interactions with cholesterol.Biophysical journal · 2006Article
- Article
- Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy.Biochemistry · 2004Article
- Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers.The Journal of biological chemistry · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lactosylceramide (LacCer) is a pivotal intermediate in the metabolism of higher gangliosides, localizes to sphingolipid-sterol "rafts," and has been implicated in cellular signaling. To provide a fundamental characterization of LacCer phase behavior and intermolecular packing, LacCer containing different saturated (16:0, 18:0, 24:0) or monounsaturated (18:1(Delta9), 24:1(Delta15)) acyl chains were synthesized and studied by differential scanning calorimetry and Langmuir film balance approaches. Compared to related sphingoid- and glycerol-based lipids, LacCers containing saturated acyl chains display relatively high thermotropic and pressure-induced transitions. LacCer monolayer films are less elastic in an in-plane sense than sphingomyelin films, but are somewhat more elastic than galactosylceramide films. Together, these findings indicate that the disaccharide headgroup only marginally disrupts gel phase packing and orients more perpendicular than parallel to the interface. This contrasts the reported behavior of digalactosyldiglycerides with saturated acyl chains. Introducing single cis double bonds into the LacCer acyl chains dramatically lowers the high thermotropic and pressure-induced transitions. Greater reductions occur when cis double bonds are located near the middle of the acyl chains. The results are discussed in terms of how an extended disaccharide headgroup can enhance interactions among naturally abundant LacCers with saturated acyl chains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.