ArticleBiophysical journal2002
Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
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- Identification of potential therapeutic targets for gliomas by bioinformatics analysis.Oncology letters · 2017Article
- Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.Journal of computational neuroscience · 2016Article
- Immobilized IL-8 Triggers Phagocytosis and Dynamic Changes in Membrane Microtopology in Human Neutrophils.Annals of biomedical engineering · 2015Article
- Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology.Biophysical journal · 2015Article
- Quantitative analysis of protein and gene expression in salivary glands of Sjogren's-like disease NOD mice treated by bone marrow soup.PloS one · 2014Article
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- Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.Frontiers in computational neuroscience · 2012Article
- Bioinformatics and systems biology of the lipidome.Chemical reviews · 2011Review
- Stochastic hybrid modeling of intracellular calcium dynamics.The Journal of chemical physics · 2010Article
- Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling.Cellular and molecular life sciences : CMLS · 2010Review
- Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage.Journal of theoretical biology · 2010Article
- Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes.Journal of biological physics · 2009Article
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- Diphosphoinositol polyphosphates: metabolic messengers?Molecular pharmacology · 2009Review
- Multimodal encoding in a simplified model of intracellular calcium signaling.Cognitive processing · 2009Article
- A dual receptor crosstalk model of G-protein-coupled signal transduction.PLoS computational biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inositol phosphates function as second messengers for a variety of extracellular signals. Ins(1,4,5)P(3) generated by phospholipase C-mediated hydrolysis of phosphatidylinositol bisphosphate, triggers numerous cellular processes by regulating calcium release from internal stores. The Ins(1,4,5)P(3) signal is coupled to a complex metabolic cascade involving a series of phosphatases and kinases. These enzymes generate a range of inositol phosphate derivatives, many of which have signaling roles of their own. We have integrated published biochemical data to build a mass action model for InsP(3) metabolism. The model includes most inositol phosphates that are currently known to interact with each other. We have used this model to study the effects of a G-protein coupled receptor stimulus that activates phospholipase C on the inositol phosphates. We have also monitored how the metabolic cascade interacts with Ins(1,4,5)P(3)-mediated calcium release. We find temporal dynamics of most inositol phosphates to be strongly influenced by the elaborate networking. We also show that Ins(1,3,4,5)P(4) plays a key role in InsP(3) dynamics and allows for paired pulse facilitation of calcium release. Calcium oscillations produce oscillatory responses in parts of the metabolic network and are in turn temporally modulated by the metabolism of InsP(3).
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