Evidence map›Paper›PMID 12200681›Full record

ArticleLeukemia2002

Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes.

D Ribatti, G Polimeno, A Vacca, A Marzullo, E Crivellato, B Nico, G Lucarelli, F Dammacco

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 71 citations in OpenAlex.

  1. Tryptase and tumor angiogenesis.Frontiers in oncology · 2024
    Review
  2. Review
  3. Article
  4. Mast Cells and Angiogenesis in Human Plasma Cell Malignancies.International journal of molecular sciences · 2019
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Mast cells and angiogenesis in gastric carcinoma.International journal of experimental pathology · 2010
    Article
  12. Article
  13. Immune cells and angiogenesis.Journal of cellular and molecular medicine · 2009
    Review
  14. Article
  15. Adipocytes, mast cells and angiogenesis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

D RibattiDepartment of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
G Polimeno
A Vacca
A Marzullo
E Crivellato
B Nico
G Lucarelli
F Dammacco
University of Bari Aldo Moro · ITOspedale Generale Regionale Francesco Miulli · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

Indexed as

Antigens, CD34Bone MarrowDisease ProgressionHumansImmunoenzyme TechniquesMast CellsMicrocirculationMyelodysplastic SyndromesNeovascularization, PathologicSerine EndopeptidasesTryptasesAntigens, CD34Serine EndopeptidasesTryptases

Identifiers

PMID12200681
OpenAlexW2316237018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.