ArticleApplied and environmental microbiology2002
Fumarate-mediated inhibition of erythrose reductase, a key enzyme for erythritol production by Torula corallina.
Article in Applied and environmental microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
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- Computational method for mapping mass signatures along developmental gradients reveals a novel role for a monosaccharide tetrose in maize salt-stress response.bioRxiv : the preprint server for biology · 2025Article
- Comparative Transcriptome Analysis Reveals Key Genes Related to Erythritol Production inInternational journal of molecular sciences · 2025Article
- Multiplex modification of Yarrowia lipolytica for enhanced erythritol biosynthesis from glycerol through modularized metabolic engineering.Bioprocess and biosystems engineering · 2023Article
- Enhancing erythritol production from crude glycerol in a wild-typeFrontiers in microbiology · 2022Article
- Biomass allocation in response to accession recognition inPlant signaling & behavior · 2021Article
- Metabolic engineering of the oleaginous yeast Yarrowia lipolytica PO1f for production of erythritol from glycerol.Biotechnology for biofuels · 2021Article
- TCA cycle signalling and the evolution of eukaryotes.Current opinion in biotechnology · 2021Review
- Metabolic engineering ofBiotechnology for biofuels · 2020Article
- Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering.Microbial cell factories · 2018Article
- Erythritol production byFood science and biotechnology · 2017Article
- Mineral supplementation increases erythrose reductase activity in erythritol biosynthesis from glycerol by Yarrowia lipolytica.Applied biochemistry and biotechnology · 2014Article
- Identification of a newly isolated erythritol-producing yeast and cloning of its erythrose [corrected] reductase genes.Journal of industrial microbiology & biotechnology · 2012Article
- Molecular cloning and biochemical characterization of a novel erythrose reductase from Candida magnoliae JH110.Microbial cell factories · 2010Article
- Purification and characterization of a novel erythrose reductase from Candida magnoliae.Applied and environmental microbiology · 2003Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Torula corallina, a strain presently being used for the industrial production of erythritol, has the highest erythritol yield ever reported for an erythritol-producing microorganism. The increased production of erythritol by Torula corallina with trace elements such as Cu(2+) has been thoroughly reported, but the mechanism by which Cu(2+) increases the production of erythritol has not been studied. This study demonstrated that supplemental Cu(2+) enhanced the production of erythritol, while it significantly decreased the production of a major by-product that accumulates during erythritol fermentation, which was identified as fumarate by instrumental analyses. Erythrose reductase, a key enzyme that converts erythrose to erythritol in T. corallina, was purified to homogeneity by chromatographic methods, including ion-exchange and affinity chromatography. In vitro, purified erythrose reductase was significantly inhibited noncompetitively by increasing the fumarate concentration. In contrast, the enzyme activity remained almost constant regardless of Cu(2+) concentration. This suggests that supplemental Cu(2+) reduced the production of fumarate, a strong inhibitor of erythrose reductase, which led to less inhibition of erythrose reductase and a high yield of erythritol. This is the first report that suggests catabolite repression by a tricarboxylic acid cycle intermediate in T. corallina.
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