ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2002
Localization of human SMC1 protein at kinetochores.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown.American journal of cancer research · 2021Article
- Sex differences in the late first trimester human placenta transcriptome.Biology of sex differences · 2018Article
- Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.International journal of biological sciences · 2017Review
- Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.Molecular biology of the cell · 2009Article
- Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks.Molecular systems biology · 2007Article
- cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.Oncogene · 2004Article
- Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores.EMBO reports · 2004Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Proper cohesion of sister chromatids is prerequisite for correct segregation of chromosomes during cell division. The cohesin multiprotein complex, conserved in eukaryotes, is required for sister chromatid cohesion. Human cohesion is composed of a stable heterodimer of the structural maintenance of chromosomes (SMC) family proteins, hSMC1 and hSMC3, and non-SMC components, hRAD21 and SA1 (or SA2). In yeast, cohesion associates with chromosomes from late G1 to metaphase and is required for the establishment and maintenance of both chromosome arm and centromeric cohesion. However, in human cells, the majority of cohesion dissociates from chromosomes before mitosis. Although it was recently shown that a small amount of hRAD21 localizes to the centromeres during metaphase, the presence of other cohesion components at the centromere has not been demonstrated in human cells. Here we report the mitosis-specific localization of hSMC1 to the kinetochores. hSMC1 is targeted to the kinetochore region during prophase concomitant with kinetochore assembly and remains through anaphase. Importantly, hSMC1 is targeted only to the active centromere on dicentric chromosomes. These results suggest that hSMC1 is an integral component of the functional kinetochore structure during mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.