ReviewJournal of autism and developmental disorders2002
Brief report: immune factors in autism: a critical review.
Review in Journal of autism and developmental disorders, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Autism from a biometric perspective.International journal of environmental research and public health · 2010Trial
- Immune regulation of neurodevelopment at the mother-foetus interface: the case of autism.Clinical & translational immunology · 2020Review
- Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders.ISRN nutrition · 2014Review
- Article
- Serum levels of soluble platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 are decreased in subjects with autism spectrum disorder.Molecular autism · 2013Article
- Modeling autism: a systems biology approach.Journal of clinical bioinformatics · 2012Article
- Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old.Archives of medical science : AMS · 2012Article
- Article
- Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism.Dermato-endocrinology · 2009Article
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Article
- Maternal infection and white matter toxicity.Neurotoxicology · 2006Review
- Chronomics of autism and suicide.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2005Article
- Behavioral heterogeneity in an animal model of neuropsychiatric lupus.Biological psychiatry · 2005Article
- Autistic disorder and viral infections.Journal of neurovirology · 2005Review
- Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications.Drugs · 2005Review
- Long-chain polyunsaturated fatty acids in childhood developmental and psychiatric disorders.Lipids · 2004Review
- Autism and abnormal development of brain connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Review
- Autism as a disorder of neural information processing: directions for research and targets for therapy.Molecular psychiatry · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pervasive developmental disorders represent a group of neurodevelopmental disorders that affect children early in their development. Autistic disorder is the best described of these disorders, yet even this term covers a broad group of clinical presentations. Various immune system abnormalities, including autoimmunity and defects in different subsets of immune cells, have been reported in children with autistic disorder, suggesting that immune factors may play a role in the development of autism. Based on anecdotal observation, vaccination was proposed to cause autism in some children, but several controlled studies have failed to support this claim. Intravenous immunoglobulin infusions has been tested as immunotherapy for autism, although the preliminary results are inconclusive and there is a risk of potentially fatal transmission of blood-borne pathogens. To examine this issue, intensive well-controlled epidemiological and bench studies need to be carried out in defined and carefully controlled study subjects to establish the cellular and molecular basis of autism, against which the effects of each proposed immune factor can be examined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.