ArticleThe EMBO journal2002
A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice.European thyroid journal · 2025Article
- ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve.iScience · 2022Article
- Myelin Biology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Article
- Validation of a NovelFrontiers in cell and developmental biology · 2021Article
- Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury.Frontiers in molecular neuroscience · 2020Article
- The correlation between insulin and OCT-6 transcription factor in Schwann cells and sciatic nerve of diabetic rats.Genes & diseases · 2018Article
- Regulatory Logic Underlying Diversification of the Neural Crest.Trends in genetics : TIG · 2017Review
- Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.Nature communications · 2017Article
- Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve.PloS one · 2016Article
- New insights on Schwann cell development.Glia · 2015Review
- Transcriptional control of spermatogonial maintenance and differentiation.Seminars in cell & developmental biology · 2014Review
- NF-κB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A role for Schwann cell-derived neuregulin-1 in remyelination.Nature neuroscience · 2013Article
- Genome-scale study of transcription factor expression in the branching mouse lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.Nature neuroscience · 2011Article
- Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.BMC cell biology · 2010Article
- The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells.Biology of reproduction · 2010Article
- Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While an important role for the POU domain transcription factor Oct-6 in the developing peripheral nerve has been well established, studies into its exact role in nerve development and regeneration have been hampered by the high mortality rate of newborn Oct-6 mutant animals. In this study we have generated a Schwann cell-specific Oct-6 allele through deletion of the Schwann cell-specific enhancer element (SCE) in the Oct-6 locus. Analysis of mice homozygous for this allele (deltaSCE allele) reveals that rate-limiting levels of Oct-6 in Schwann cells are dependent on the SCE and that this element does not contribute to Oct-6 regulation in other cell types. We demonstrate a Schwann cell autonomous function for Oct-6 during nerve development as well as in regenerating nerve. Additionally, we show that Krox-20, an important regulatory target of Oct-6 in Schwann cells, is activated, with delayed kinetics, through an Oct-6-independent mechanism in these mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.