ArticleThe EMBO journal2002
An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Reduction of TRPC1/TRPC3 mediated CaCellular signalling · 2023Article
- Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.Nature metabolism · 2022Article
- Pathophysiological role of calcium channels and transporters in the multiple myeloma.Cell communication and signaling : CCS · 2021Review
- Electron Microscopic and Immunohistochemical Examination of the Effect of 2-Aminoethoxydiphenyl Borate on Optic Nerve Injury in A Rat Model.The Eurasian journal of medicine · 2020Article
- InsPBMC biology · 2018Article
- Effects of thrombin and thrombin receptor activation on cardiac function after acute myocardial infarction.American journal of translational research · 2015Article
- Article
- Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells.Cell cycle (Georgetown, Tex.) · 2013Article
- Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.Journal of cell science · 2010Article
- Ca(2+) channels on the move.Biochemistry · 2009Review
- Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes.Journal of molecular and cellular cardiology · 2008Review
- Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation.The Journal of physiology · 2008Article
- Organization and function of TRPC channelosomes.Pflugers Archiv : European journal of physiology · 2007Review
- Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.The Journal of cell biology · 2007Article
- Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism.The Journal of biological chemistry · 2006Article
- Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.Sub-cellular biochemistry · 2006Review
- Functional analysis of the green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3 in Ca(2+) release and entry in DT40 B lymphocytes.The Biochemical journal · 2004Article
- Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis.Gastroenterology · 2003Article
- Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We examined the roles of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) in calcium signaling using DT40 B lymphocytes, and a variant lacking the three IP3R isoforms (IP3R-KO). In wild-type cells, B cell receptor (BCR) stimulation activates a cation entry route that exhibits significantly greater permeability to Ba2+ than does capacitative calcium entry. This cation entry is absent in IP3R-KO cells. Expression of the type-3 IP3R (IP3R-3) in the IP3R-KO cells rescued not only agonist-dependent release of intracellular Ca2+, but also Ba2+ influx following receptor stimulation. Similar results were obtained with an IP3R-3 mutant carrying a conservative point mutation in the selectivity filter region of the channel (D2477E); however, an IP3R-3 mutant in which this same aspartate was replaced by alanine (D2477A) failed to restore either BCR-induced Ca2+ release or receptor-dependent Ba2+ entry. These results suggest that in DT40 B lymphocytes, BCR stimulation activates a novel cation entry across the plasma membrane that depends upon, or is mediated by, fully functional IP3R.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.