Trial reportClinical and experimental immunology2002
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates.
Trial report in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Justified concern or exaggerated fear: the risk of anaphylaxis in percutaneous treatment of cystic echinococcosis-a systematic literature review.PLoS neglected tropical diseases · 2011Pooled it
- Prevesical hydatid cyst: A case report.Clinical case reports · 2023Article
- Bacterial Infection of an Alveolar Echinococcus Cyst fromMedicina (Kaunas, Lithuania) · 2023Review
- Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response.Parasites & vectors · 2023Article
- Case Series of Cystic Echinococcosis Over a Twelve-year Period at Sultan Qaboos University Hospital, Oman.Oman medical journal · 2023Article
- Detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study.PLoS neglected tropical diseases · 2022Article
- Membrane Technology for Rapid Point-of-Care Diagnostics for Parasitic Neglected Tropical Diseases.Clinical microbiology reviews · 2021Article
- The effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Promising proteins detected by Western blot from Echinococcus granulosus protoscoleces for predicting early post-surgical outcomes in CE-affected Tunisian children.Parasites & vectors · 2021Article
- Gallbladder Hydatid Cyst: A Review on Clinical Features, Investigations and Current Management.Clinical and experimental gastroenterology · 2020Review
- Ultrasound and Cystic Echinococcosis.Ultrasound international open · 2018Review
- Pathological fracture of femoral neck in a middle-aged woman: a rare presentation of primary hydatid cyst disease in humans.BMJ case reports · 2018Article
- Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis.PLoS neglected tropical diseases · 2016Article
- Factors Influencing the Serological Response in Hepatic Echinococcus granulosus Infection.The American journal of tropical medicine and hygiene · 2016Article
- Long-term sonographic and serological follow-up of inactive echinococcal cysts of the liver: hints for a "watch-and-wait" approach.PLoS neglected tropical diseases · 2014Article
- Host-parasite relationship in cystic echinococcosis: an evolving story.Clinical & developmental immunology · 2012Review
- Long-term albendazole effectiveness for hepatic cystic echinococcosis.The American journal of tropical medicine and hygiene · 2011Article
- Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China.PLoS neglected tropical diseases · 2011Article
- Hydatid cyst of head of pancreas mimicking choledochal cyst.BMJ case reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seeking better immunological markers indicating the long-term outcome of cystic echinococcosis (CE) after chemotherapy we studied 23 patients receiving albendazole, clinically followed for 8 years, and grouped ultrasonographically according to therapeutic outcome. Antibody responses against a partially purified fraction of hydatid fluid (HFF) and antigen B (AgB) were evaluated by indirect haemagglutination (IHA), ELISA and immunoblotting (IB). Although IHA titres varied over the course of treatment, differences in mean antibody titres to HFF between groups were significant only at 4 years (P = 0.031). IgG isotype expression remained unchanged during follow-up whereas IgE expression decreased in patients with cured or stable disease. AgB disclosed higher IgG4 expression (P < 10(-4); P = 0.025) and lower IgG1 expression than HFF (P < 10(-4); P = 0.022). IHA antibody titres were higher in patients with progressive than in those with cured or stable disease, even in those with the same cyst type. ELISA isotype profiles differed between groups, particularly for type CE 3, 4 and 5 cysts: higher serum IgG1 and IgG3, lower IgG4 and IgE in patients with cured or stable disease. Although combined serological testing provides scarce information on the long-term outcome of CE after chemotherapy it may be useful for reviewing in a retrospective study the outcome of a cyst and for assessing the host-parasite relationship.
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