ArticleProceedings of the National Academy of Sciences of the United States of America2002
Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 96 citations in OpenAlex.
- Promoter- and enhancer-dependent cohesin loading initiates chromosome looping to fold Tcrb loci for long-range recombination.Cell reports · 2025Article
- Knockdown of USF1 and USF2 drives prolonged changes in the gene expression response of M12-5B3 cells to DNA damage.PloS one · 2025Article
- Locus folding mechanisms determine modes of antigen receptor gene assembly.The Journal of experimental medicine · 2024Article
- Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Nucleic acids research · 2020Article
- A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.Immunity, inflammation and disease · 2017Article
- Influence of a CTCF-Dependent Insulator on Multiple Aspects of Enhancer-Mediated Chromatin Organization.Molecular and cellular biology · 2015Article
- Histone reader BRWD1 targets and restricts recombination to the Igk locus.Nature immunology · 2015Article
- Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.The Journal of experimental medicine · 2015Article
- A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase.The Journal of biological chemistry · 2012Article
- DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Recombination centres and the orchestration of V(D)J recombination.Nature reviews. Immunology · 2011Review
- Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization.Genetics research international · 2011Article
- The center of accessibility: Dβ control of V(D)J recombination.Archivum immunologiae et therapiae experimentalis · 2010Review
- Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.Seminars in immunology · 2010Review
- Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- Promoter activity 5' of Dbeta2 is coordinated by E47, Runx1, and GATA-3.Molecular immunology · 2009Article
- A streamlined method for rapid and sensitive chromatin immunoprecipitation.Journal of immunological methods · 2009Article
- The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.European journal of immunology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Antigen receptor gene assembly is regulated by transcriptional promoters and enhancers, which control the accessibility of gene segments to a lymphocyte-specific V(D)J recombinase. However, it remained unclear whether accessibility depends on the process of transcription itself or chromatin modifications that accompany transcription. By using T cell receptor beta substrates that integrate stably into nuclear chromatin, we show that promoter location, rather than germ-line transcription or histone acetylation, is a primary determinant of recombination efficiency. These spatial constraints on promoter positioning may reflect an RNA polymerase-independent mechanism to target adjacent gene segments for chromatin remodeling events that facilitate rearrangement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.