ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cytochrome c folding pathway: kinetic native-state hydrogen exchange.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 116 citations in OpenAlex.
- Protein Structural Characterization Using Electron Transfer Dissociation and Hydrogen Exchange-Mass Spectrometry.Bio-protocol · 2025Article
- HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Open-Bundle Structure as the Unfolding Intermediate of CytochromeBiomolecules · 2022Article
- How to Turn an Electron Transfer Protein into a Redox Enzyme for Biosensing.Molecules (Basel, Switzerland) · 2021Review
- POPPeT: a New Method to Predict the Protection Factor of Backbone Amide Hydrogens.Journal of the American Society for Mass Spectrometry · 2019Article
- The K79G Mutation Reshapes the Heme Crevice and Alters Redox Properties of Cytochrome c.Biochemistry · 2018Article
- The case for defined protein folding pathways.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- How cooperative are protein folding and unfolding transitions?Protein science : a publication of the Protein Society · 2016Review
- Cytochrome c folds through foldon-dependent native-like intermediates in an ordered pathway.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The nature of protein folding pathways.Proceedings of the National Academy of Sciences of the United States of America · 2014Review
- Capping motifs stabilize the leucine-rich repeat protein PP32 and rigidify adjacent repeats.Protein science : a publication of the Protein Society · 2014Article
- Becoming a peroxidase: cardiolipin-induced unfolding of cytochrome c.The journal of physical chemistry. B · 2013Article
- Investigations of the low-frequency spectral density of cytochrome c upon equilibrium unfolding.The journal of physical chemistry. B · 2013Article
- Protein dynamics viewed by hydrogen exchange.Protein science : a publication of the Protein Society · 2012Article
- Structural and kinetic mapping of side-chain exposure onto the protein energy landscape.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mechanisms of m-cresol-induced protein aggregation studied using a model protein cytochrome c.Journal of pharmaceutical sciences · 2011Article
- Article
- Biomolecular NMR data analysis.Progress in nuclear magnetic resonance spectroscopy · 2010Review
- Native state dynamics drive the unfolding of the SH3 domain of PI3 kinase at high denaturant concentration.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each. Results obtained define a cytochrome c intermediate seen only poorly before and place it early on the major unfolding pathway. Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.