ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Identification and characterization of the feeding circuit-activating peptides, a novel neuropeptide family of aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
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- Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs.Frontiers in physiology · 2021Article
- Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death.The Journal of experimental biology · 2018Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- A Multifaceted Mass Spectrometric Method to Probe Feeding Related Neuropeptide Changes in Callinectes sapidus and Carcinus maenas.Journal of the American Society for Mass Spectrometry · 2018Article
- Exploring the Sea Urchin Neuropeptide Landscape by Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- RFamidergic neurons in the olfactory centers of the terrestrial slugZoological letters · 2018Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- Use of theJournal of neurophysiology · 2017Review
- Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection.Parasites & vectors · 2017Article
- Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators.Journal of neurophysiology · 2016Article
- Functional Characterization of a Vesicular Glutamate Transporter in an Interneuron That Makes Excitatory and Inhibitory Synaptic Connections in a Molluscan Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We use a multidisciplinary approach to identify, map, and characterize the bioactivity of modulatory neuropeptides in the circuitry that generates feeding behavior in Aplysia. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of the cerebral-buccal connective (CBC), a nerve containing axons of many interneurons that control feeding behavior of Aplysia, was used to identify neuropeptides that may participate in generation and shaping of feeding motor programs. Using this functionally oriented search, we identified a novel family of peptides that we call the feeding circuit-activating peptides (FCAPs). Two peptides with masses identical to those observed in the CBCs (molecular weight 1387 and 1433) were purified from buccal ganglia and partially sequenced using mass spectrometry. The amino acid sequence was then used to clone the FCAP precursor, which encodes multiple copies of eight different FCAPs. The two FCAPs present in highest copy number correspond to those observed in the CBC. The distribution of FCAP expression was mapped using Northern analysis, whole-mount in situ hybridization, and immunocytochemistry. Consistent with our initial findings, FCAP-immunopositive axons were observed in the CBC. Furthermore, we found that FCAP was present in some cerebral-buccal and buccal-cerebral interneurons. As their name suggests, FCAPs are capable of initiating rhythmic feeding motor programs and are the first neuropeptides with such activity in this circuit. The actions of FCAPs suggest that these peptides may contribute to the induction and maintenance of food-induced arousal. FCAPs were also localized to several other neuronal systems, suggesting that FCAPs may play a role in the regulation of multiple behaviors.
Indexed as
Identifiers
12196603PMC6757975W2161322177What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.