ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- The dual roles of chemokines in peripheral nerve injury and repair.Inflammation and regeneration · 2025Review
- ASCL2 is a key regulator of the proliferation-differentiation equilibrium in the esophageal epithelium.Biology open · 2024Article
- The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and sciatic nerve demyelination in rats.Clinical and experimental immunology · 2023Article
- TNFα-induced Up-regulation ofAging and disease · 2019Article
- Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells.eLife · 2018Article
- Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors.Development (Cambridge, England) · 2017Article
- A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.Epigenetics · 2016Article
- Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP).Journal of neuroinflammation · 2016Article
- Gene expression profiling studies in regenerating nerves in a mouse model for CMT1X: uninjured Cx32-knockout peripheral nerves display expression profile of injured wild type nerves.Experimental neurology · 2015Article
- Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells.Journal of clinical immunology · 2014Review
- DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma.BMC cancer · 2014Article
- Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling.Frontiers in cellular neuroscience · 2013Article
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- Negative regulators of schwann cell differentiation-novel targets for peripheral nerve therapies?Journal of clinical immunology · 2013Review
- MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure.Nucleic acids research · 2012Article
- Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy.Molecular pain · 2009Article
- Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands.Developmental biology · 2008Article
- The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy.Brain, behavior, and immunity · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular control mechanisms and regulatory molecules involved in nerve repair are not yet well known. Schwann cells have been attributed an important role in peripheral nerve regeneration; therefore, attention has been drawn to regulatory factors expressed by these glial cells. Here, we demonstrate that Mash2, a basic helix-loop-helix (bHLH) transcription factor previously shown to be crucial for placenta development, is expressed by Schwann cells of adult peripheral nerves. We observed that this gene is downregulated after nerve lesion and, using cDNA array hybridization technology, we could demonstrate that Mash2 is a regulator of Krox24, Mob-1, and CXCR4 expression in cultured Schwann cells. In addition, we provide strong evidence that Mash2 is a negative regulator of Schwann cell proliferation. Mash2 represents a first candidate for the missing class B bHLH proteins in peripheral nerves.
Indexed as
Identifiers
12196582PMC6758000W2167645829What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.