ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Neocortical long-term potentiation and long-term depression: site of expression investigated by infrared-guided laser stimulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Bioelectric; Neuromodulation; Epilepsy; DBS; High-frequency stimulation; Low frequency stimulation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight.Nature communications · 2024Article
- Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex.Nature communications · 2022Article
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- Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior.Brain sciences · 2019Review
- Optogenetic evocation of field inhibitory postsynaptic potentials in hippocampal slices: a simple and reliable approach for studying pharmacological effects on GABAA and GABAB receptor-mediated neurotransmission.Frontiers in cellular neuroscience · 2014Article
- Synapses of horizontal connections in adult rat somatosensory cortex have different properties depending on the source of their axons.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Plasticity between neuronal pairs in layer 4 of visual cortex varies with synapse state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.Neural plasticity · 2009Article
- Synaptic mechanisms for plasticity in neocortex.Annual review of neuroscience · 2009Review
- Long-term potentiation of exogenous glutamate responses at single dendritic spines.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Neurobiology of rehabilitation.Annals of the New York Academy of Sciences · 2004Review
- Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synaptic site of expression of long-term potentiation (LTP) and long-term depression (LTD) is still a matter of debate. To address the question of presynaptic versus postsynaptic expression of neocortical LTP and LTD in a direct approach, we measured the glutamate sensitivity of apical dendrites of layer 5 pyramidal neurons during LTP and LTD. We used infrared-guided laser stimulation to release glutamate from its "caged" form with high spatial and temporal resolution. Responses to photolytically released glutamate and synaptically evoked EPSPs were recorded with patch-clamp pipettes from the neuronal somata. LTP and LTD could be induced by electrical stimulation at the same synapses in succession. The NMDA receptor-dependent LTD was accompanied by a decrease in the dendritic glutamate sensitivity, suggesting a postsynaptic expression of neocortical LTD. In contrast, LTP was never accompanied by a change in the dendritic glutamate sensitivity. A possible explanation for this finding is a presynaptic expression of neocortical LTP. Another set of experiments corroborated these results: Photolytic application of glutamate with a frequency of 5 Hz caused a long-lasting Ca2+ and NMDA receptor-dependent decrease in the dendritic glutamate sensitivity. In contrast, LTP of dendritic glutamate sensitivity was never induced by photostimulation, despite several experimental modifications to prevent washout of the induction mechanism and to induce a stronger postsynaptic Ca2+ influx. In conclusion, our findings provide strong evidence for a postsynaptic expression of neocortical LTD and favor a primarily presynaptic locus of neocortical LTP.
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Identifiers
12196579PMC6758004W1602375810What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.