ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Dynamic pattern of reg-2 expression in rat sensory neurons after peripheral nerve injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I.Science advances · 2025Article
- Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.International journal of molecular sciences · 2023Article
- Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by Activating Spinal Microglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis.Frontiers in neuroanatomy · 2016Article
- Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis.Acta neuropathologica communications · 2015Article
- HIP/PAP prevents excitotoxic neuronal death and promotes plasticity.Annals of clinical and translational neurology · 2014Article
- N-terminal cleaved pancreatitis-associated protein-III (PAP-III) serves as a scaffold for neurites and promotes neurite outgrowth.The Journal of biological chemistry · 2013Article
- Article
- Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.The Journal of biological chemistry · 2012Article
- Activating transcription factor 3 and the nervous system.Frontiers in molecular neuroscience · 2012Article
- Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain.Cellular and molecular neurobiology · 2011Article
- Essential role of monocytes and macrophages in the progression of acute pancreatitis.World journal of gastroenterology · 2010Review
- Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons.Molecular pain · 2010Article
- Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain.European journal of pain (London, England) · 2009Article
- Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells.BMC genomics · 2009Article
- Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.World journal of gastroenterology · 2007Review
- Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons.Anesthesiology · 2006Article
- Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes.BMC gastroenterology · 2006Article
- Reg gene family and human diseases.World journal of gastroenterology · 2003Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The 16 kDa pancreatitis-associated protein Reg-2 has recently been shown to facilitate the regeneration of motor and sensory neurons after peripheral nerve injury in the adult rat. Reg-2 has also been shown to be a neurotrophic factor that is an essential intermediate in the pathways through which CNTF supports the survival of motor neurons during development. Here we report the dynamic expression of Reg-2 in rat sensory neurons after peripheral nerve injury. Reg-2 is normally not expressed by dorsal root ganglion (DRG) cells, but we show, using immunocytochemistry, that Reg-2 is rapidly upregulated in DRG cells after sciatic nerve transection and after 24 hr recovery is expressed almost exclusively in small-diameter neurons that bind the lectin Griffonia simplicifolia IB4 and express the purinoceptor P2X3. However, by 7 d after axotomy, Reg-2 is expressed in medium to large neurons and coexists partly with the neuropeptides galanin and neuropeptide Y, which are also upregulated after peripheral nerve transection. At this time point, Reg-2 is no longer expressed in small neurons, and there is no colocalization with IB4 binding neurons, demonstrating a shift in Reg-2 expression from one subset of DRG neurons to another. We also show by double labeling for activating transcription factor 3, a transcription factor that is upregulated after nerve injury, that Reg-2 expression occurs predominantly in axotomized DRG cells but that a small percentage of uninjured DRG cells also upregulate Reg-2. The selective expression within IB4/P2X3 cells, and the dynamic shift from small to large cells, is unique among DRG peptides and suggests that Reg-2 has a distinctive role in the injury response.
Indexed as
Identifiers
12196572PMC6757959W2118352181What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.